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MMP1 抗体 (HRP)

MMP1 适用: 人 WB, IHC (p), IHC (fro), EIA 宿主: 小鼠 Monoclonal SB12e HRP
产品编号 ABIN371652
发货至: 中国
  • 抗原 See all MMP1 抗体
    MMP1 (Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1))
    适用
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    宿主
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    小鼠
    克隆类型
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    单克隆
    标记
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    This MMP1 antibody is conjugated to HRP
    应用范围
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    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)
    特异性
    This antibody is specific for Human MMP-1. Does not cross react to human MMP-2, MMP-3 or MMP-9.
    产品特性
    Synonyms: Interstitial collagenase, Matrix metalloproteinase-1, Fibroblast collagenase, MMP1, CLG
    免疫原
    Recombinant MMP-1.
    克隆位点
    SB12e
    亚型
    IgG2b
    Top Product
    Discover our top product MMP1 Primary Antibody
  • 应用备注
    ELISA: 1/1,000-1/4,000. Western Blot. Immunohistochemistry (Frozen/Paraffin): 1/1,000-1/2,000.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    50 % Glycerol/50 % PBS, pH 7.4 without preservatives.
    储存液
    Without preservative
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody undiluted at 2-8 °C for one month or in (aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
    Shelf life: one year from despatch.
    有效期
    12 months
  • 抗原
    MMP1 (Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1))
    别名
    MMP-1 (MMP1 产品)
    别名
    CLG antibody, CLGN antibody, Mmp1a antibody, CG4859 antibody, Dm1-MMP antibody, Dmel\\CG4859 antibody, MMP-1 antibody, MMP1 antibody, Mmp 1 antibody, dMMP1 antibody, dm1-MMP antibody, dmmp1 antibody, l(2)k04809 antibody, mmp1 antibody, Mmp1 antibody, Mcol-A antibody, Mcola antibody, col4 antibody, mmp18 antibody, Clgn antibody, matrix metallopeptidase 1 antibody, Matrix metalloproteinase 1 antibody, matrix metalloproteinase 1 antibody, matrix metallopeptidase 1 (interstitial collagenase) antibody, matrix metallopeptidase 1a (interstitial collagenase) antibody, matrix metallopeptidase 1 S homeolog antibody, interstitial collagenase antibody, matrix metallopeptidase 8 L homeolog antibody, MMP1 antibody, Mmp1 antibody, RB11133 antibody, Mmp1a antibody, mmp1.S antibody, LOC100727966 antibody, mmp8.L antibody
    背景
    The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane bound zincendopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc binding site characterizes the structure of the MMPs. In addition, fibronectin like repeats, a hinge region, and a C terminal hemopexin like domain allow categorization of MMPs into the collagenase, gelatinase, stomelysin and membrane type MMP subfamilies. All MMPs are synthesized as proenzymes, and most of them are secreted from the cells as proenzymes. Thus, the activation of these proenzymes is a critical step that leads to extracellular matrix breakdown. MMPs are considered to play an important role in wound healing, apoptosis, bone elongation, embryo development, uterine involution, angiogenesis and tissue remodeling, and in diseases such as multiple sclerosis, Alzheimer's, malignant gliomas, lupus, arthritis, periodontis, glumerulonephritis, atherosclerosis, tissue ulceration, and in cancer cell invasion and metastasis. MMP1, also known as interstitial collagenase, is the only enzyme that is able to initiate the breakdown of the interstitial collagens, types I, II, and IIISynonyms: CLG, Fibroblast collagenase, Interstitial collagenase, MMP1, Matrix metalloproteinase-1
    基因ID
    4312
    UniProt
    P03956
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