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Transferrin Receptor 抗体

TFRC 适用: 小鼠 FACS, IP, Func 宿主: 大鼠 Monoclonal RI7217 unconjugated
产品编号 ABIN370997
发货至: 中国
  • 抗原 See all Transferrin Receptor (TFRC) 抗体
    Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))
    适用
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    小鼠
    宿主
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    大鼠
    克隆类型
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    单克隆
    标记
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    This Transferrin Receptor antibody is un-conjugated
    应用范围
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    Flow Cytometry (FACS), Immunoprecipitation (IP), Functional Studies (Func)
    特异性
    This antibody recognises CD71/Transferrin Receptor, Mr 180-190 kDa (90-95 kDa under reducing conditions). RI7217 inhibits cell proliferation in vitro. (Ref.2)
    产品特性
    Synonyms: TfR1, p90, Transferrin receptor protein 1
    纯化方法
    Purified
    克隆位点
    RI7217
    亚型
    IgG2a
    Top Product
    Discover our top product TFRC Primary Antibody
  • 应用备注
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    0.5 mg/mL
    缓冲液
    100 mM Borate Buffered Saline, pH 8.2. No preservatives or amine-containing buffer salts added.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
    Shelf life: one year from despatch.
    有效期
    12 months
  • 抗原
    Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))
    别名
    CD71 / TFRC (TFRC 产品)
    背景
    CD71, a type II transmembrane glycoprotein expressed on the cell surface as a homodimer, is the Transferrin Receptor. It is essential for the growth of normal and neoplastic cells. (Ref.1,4) It is expressed at low levels on resting B and T lymphocytes but is upregulated during responses to antigens and mitogens, presumably reflecting the iron dependence of proliferation. (Ref.4) Its expression declines with maturation and differentiation. CD71 plays a critical role in cell proliferation by controlling the supply of iron, which is essential for many metabolic pathways, through the binding and endocytosis of transferrin, the major ironcarrying protein. It may also be involved in signal transduction via its association with the T cell receptor zeta chain.Synonyms: TfR1, Transferrin receptor protein 1, p90
    基因ID
    22042
    UniProt
    Q62351
    途径
    Transition Metal Ion Homeostasis
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