Transferrin Receptor 抗体 (Biotin)
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- 抗原 See all Transferrin Receptor (TFRC) 抗体
- Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))
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适用
- 小鼠
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宿主
- 大鼠
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克隆类型
- 单克隆
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标记
- This Transferrin Receptor antibody is conjugated to Biotin
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应用范围
- Flow Cytometry (FACS)
- 特异性
- This antibody recognises CD71/Transferrin Receptor, Mr 180-190 kDa (90-95 kDa under reducing conditions).
- 产品特性
- Synonyms: TfR1, p90, Transferrin receptor protein 1
- 克隆位点
- RI7217
- 亚型
- IgG2a
- Top Product
- Discover our top product TFRC Primary Antibody
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- 应用备注
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Flow Cytometry: < / = 1 μg/10^6 cells. (Ref.1-3,5)
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 浓度
- 0.5 mg/mL
- 缓冲液
- PBS containing 0.09 % Sodium Azide as preservative.
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C/-20 °C
- 储存方法
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Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch. - 有效期
- 12 months
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- 抗原
- Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))
- 别名
- CD71 / TFRC (TFRC 产品)
- 背景
- CD71, a type II transmembrane glycoprotein expressed on the cell surface as a homodimer, is the Transferrin Receptor. It is essential for the growth of normal and neoplastic cells. (Ref.1,4) It is expressed at low levels on resting B and T lymphocytes but is upregulated during responses to antigens and mitogens, presumably reflecting the iron dependence of proliferation. (Ref.4) Its expression declines with maturation and differentiation. CD71 plays a critical role in cell proliferation by controlling the supply of iron, which is essential for many metabolic pathways, through the binding and endocytosis of transferrin, the major ironcarrying protein. It may also be involved in signal transduction via its association with the T cell receptor zeta chain. Clone RI7217 inhibits cell proliferation in vitro. (Ref.2)Synonyms: TfR1, Transferrin receptor protein 1, p90
- 基因ID
- 22042
- UniProt
- Q62351
- 途径
- Transition Metal Ion Homeostasis
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