PDGFRB 抗体 (AA 749-753)
Our Local Distributor
北京 101111
Quick Overview for PDGFRB 抗体 (AA 749-753) (ABIN362878)
抗原
See all PDGFRB 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 749-753
-
特异性
- The antibody detects endogenous level of total PDGF Receptor b protein.
-
纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-
免疫原
- Peptide sequence around AA 749-753 (V-D-Y-V-P) derived from Human PDGFRb. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
-
亚型
- IgG
-
-
-
-
应用备注
- Western blotting: 1:500-1:1000
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
-
储存液
- Sodium azide
-
注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C/-20 °C
-
储存方法
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
-
-
- PDGFRB (Platelet Derived Growth Factor Receptor beta (PDGFRB))
-
别名
- PDGF Receptor beta
-
背景
- PDGF Receptor b encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor a and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor, all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.
-
分子量
- 190 kDa
-
NCBI登录号
- NP_002600
-
UniProt
- P09619
-
途径
- Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Inositol Metabolic Process, Glycosaminoglycan Metabolic Process, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling
抗原
-