PDPK1 抗体 (AA 239-243)
Quick Overview for PDPK1 抗体 (AA 239-243) (ABIN362492)
抗原
See all PDPK1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 239-243
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特异性
- The antibody detects endogenous level of total PDK1 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific immunogen.
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免疫原
- Peptide sequence around AA 239-243 (A-N-S-F-V) derived from Human PDK1. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
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亚型
- IgG
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应用备注
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Western blotting: 1:500-1:1000
Immunohistochemistry: 1:50-1:100
Immunofluorescence: 1:100-1:200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
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: "Activation of mammalian target of rapamycin pathway confers adverse outcome in nonsmall cell lung carcinoma." in: Cancer, Vol. 117, Issue 16, pp. 3763-73, (2011) (PubMed).
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: "Activation of mammalian target of rapamycin pathway confers adverse outcome in nonsmall cell lung carcinoma." in: Cancer, Vol. 117, Issue 16, pp. 3763-73, (2011) (PubMed).
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- PDPK1 (3-phosphoinositide Dependent Protein Kinase-1 (PDPK1))
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别名
- PDK1
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背景
- Phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development
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分子量
- 63 kDa
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NCBI登录号
- NP_002604
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UniProt
- O15530
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途径
- PI3K-Akt Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Regulation of Cell Size, Skeletal Muscle Fiber Development, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals
抗原
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