SNCA 抗体 (pTyr133)
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Quick Overview for SNCA 抗体 (pTyr133) (ABIN362366)
抗原
See all SNCA 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pTyr133
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特异性
- The antibody detects endogenous level of a-Synuclein only when phosphorylated at tyrosine 133.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removedby chromatography using non-phosphopeptide corresponding to the phosphorylation site.
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免疫原
- Peptide sequence around phosphorylation site of pTyr133 (E-G-Y (p) -Q-D) derived from Human a-Synuclein. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
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亚型
- IgG
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anti-Synuclein, alpha (SNCA) (pSer129) antibody
SNCA 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (PerCP)SNCA 适用: 人 WB, ELISA, IHC, ICC 宿主: 兔 Monoclonal J18 PerCP
anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (PE)SNCA 适用: 人 WB, ELISA, IHC, ICC 宿主: 兔 Monoclonal J18 PE
anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (Atto 488)SNCA 适用: 人 WB, ELISA, IHC, ICC 宿主: 兔 Monoclonal J18 Atto 488
anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (Atto 390)SNCA 适用: 人 WB, ELISA, IHC, ICC 宿主: 兔 Monoclonal J18 Atto 390
anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (Atto 594)SNCA 适用: 人 WB, ELISA, IHC, ICC 宿主: 兔 Monoclonal J18 Atto 594
anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (Biotin)SNCA 适用: 人 WB, ELISA, IHC, ICC 宿主: 兔 Monoclonal J18 Biotin
anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (FITC)SNCA 适用: 人 WB, ELISA, IHC, ICC 宿主: 兔 Monoclonal J18 FITC
anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (APC)SNCA 适用: 人 WB, ELISA, IHC, ICC 宿主: 兔 Monoclonal J18 APC
anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (HRP)SNCA 适用: 人 WB, ELISA, IHC, ICC 宿主: 兔 Monoclonal J18 HRP
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应用备注
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Western blotting: 1:500-1:1000
Immunofluorescence: 1:100-1:200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
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- SNCA (Synuclein, alpha (SNCA))
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别名
- alpha-Synuclein
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背景
- SncA is a member of the synuclein family of structurally related proteins that are prominently expressed in the central nervous system, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and SncA and Snc-Beta inhibit phospholipase D2 selectively. SncA may serve to integrate presynaptic signaling and membrane trafficking. Aggregated SncA proteins form brain lesions that are hallmarks of neurodegenerative synucleinopathies. Defects in SncA play a role in the pathogenesis of Parkinson disease. SncA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer disease. SncA shares 95% sequence homology with rat SncA. Rat SncA is specifically expressed in brain and is associated with synaptosomal membranes in neurons
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分子量
- 18 kDa
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NCBI登录号
- NP_000336
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UniProt
- P37840
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途径
- Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity
抗原
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