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tau 抗体 (pThr205)

适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN362074
发货至: 中国
  • 抗原 See all tau 抗体
    tau (tau Protein)
    抗原表位
    • 31
    • 30
    • 30
    • 26
    • 26
    • 26
    • 24
    • 23
    • 22
    • 21
    • 19
    • 18
    • 17
    • 17
    • 17
    • 17
    • 16
    • 16
    • 16
    • 16
    • 16
    • 15
    • 15
    • 15
    • 15
    • 13
    • 11
    • 9
    • 8
    • 8
    • 8
    • 7
    • 6
    • 6
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    pThr205
    适用
    • 524
    • 499
    • 498
    • 40
    • 28
    • 27
    • 18
    • 6
    • 3
    • 2
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 629
    • 35
    • 2
    • 1
    克隆类型
    • 604
    • 62
    • 1
    多克隆
    标记
    • 207
    • 40
    • 34
    • 33
    • 33
    • 33
    • 32
    • 32
    • 32
    • 30
    • 24
    • 24
    • 24
    • 24
    • 24
    • 13
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    This tau antibody is un-conjugated
    应用范围
    • 547
    • 272
    • 263
    • 205
    • 92
    • 85
    • 66
    • 59
    • 53
    • 36
    • 34
    • 16
    • 12
    • 12
    • 12
    • 9
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    特异性
    The antibody detects endogenous level of Tau only when phosphorylated at threonine 205.
    纯化方法
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
    免疫原
    Peptide sequence around phosphorylation site of pThr205 (P-G-T (p) -P-G) derived from Human Tau. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
    亚型
    IgG
    Top Product
    Discover our top product tau Primary Antibody
  • 应用备注
    Western blotting: 1:500-1:1000
    Immunohistochemistry: 1:50-1:100
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C/-20 °C
    储存方法
    Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
  • Sun, Wei, Xiong, Wang, Xie, Wang, Yang, Wang, Lu, Liu, Wang: "Synaptic released zinc promotes tau hyperphosphorylation by inhibition of protein phosphatase 2A (PP2A)." in: The Journal of biological chemistry, Vol. 287, Issue 14, pp. 11174-82, (2012) (PubMed).

    Chen, Xiong, Kong, Qu, Wang, Chen, Wang, Zhu: "Neuroglobin attenuates Alzheimer-like tau hyperphosphorylation by activating Akt signaling." in: Journal of neurochemistry, Vol. 120, Issue 1, pp. 157-64, (2011) (PubMed).

    Tan, Cao, Wang, Lv, Wu, Ma: "Tau hyperphosphorylation is associated with memory impairment after exposure to 1.5% isoflurane without temperature maintenance in rats." in: European journal of anaesthesiology, Vol. 27, Issue 9, pp. 835-41, (2010) (PubMed).

    Tan, Cao, Wang, Lv, Wu, Ma: "Protective effects of lithium treatment for spatial memory deficits induced by tau hyperphosphorylation in splenectomized rats." in: Clinical and experimental pharmacology & physiology, Vol. 37, Issue 10, pp. 1010-5, (2010) (PubMed).

  • 抗原
    tau (tau Protein)
    别名
    Tau (tau 产品)
    别名
    DDPAC antibody, FTDP-17 antibody, MAPTL antibody, MSTD antibody, MTBT1 antibody, MTBT2 antibody, PPND antibody, TAU antibody, tau antibody, PHF-tau antibody, microtubule associated protein tau antibody, MAPT antibody
    背景
    Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
    分子量
    78 kDa
    UniProt
    P10636
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