GABRG2 抗体 (pSer327)
(1 reference)Quick Overview for GABRG2 抗体 (pSer327) (ABIN361470)
抗原
See all GABRG2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer327
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特异性
- Specific for ~45k GABAA receptor gamma2 subunit phosphorylated at Ser327. Immunolabeling of the GABAA band is completely blocked by lambda phosphatase treatment.
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交叉反应
- 小鼠, 大鼠
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预测反应
- bovine, canine, chicken, human, non-human primate
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纯化方法
- Antigen Affinity Purified from Pooled Serum
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免疫原
- Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser327 conjugated to KLH
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anti-gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2) (AA 41-140) antibody
GABRG2 适用: 人, 小鼠, 大鼠, 兔 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2) (N-Term) antibodyGABRG2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2) (AA 170-270) antibodyGABRG2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2) (AA 198-224) antibodyGABRG2 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB23939 unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2) antibodyGABRG2 适用: 人, 小鼠, 大鼠 IP, ICC 宿主: 小鼠 Monoclonal 331A12 unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2) (AA 198-224) antibodyGABRG2 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2) (AA 42-108) antibodyGABRG2 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2) (AA 61-110) antibodyGABRG2 适用: 人, 小鼠, 大鼠, 兔, Cow, 犬, Pig, 马, 豚鼠, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2) (N-Term) antibodyVerified GABRG2 适用: 大鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2) (AA 36-85) antibodyGABRG2 适用: 人, 小鼠, 大鼠, 兔, Cow, 犬, Pig, 马, 豚鼠, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 100 μL in 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.
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储存条件
- -20 °C
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: "Differential regulation of synaptic and extrasynaptic α4 GABA(A) receptor populations by protein kinase A and protein kinase C in cultured cortical neurons." in: Neuropharmacology, Vol. 105, pp. 124-32, (2016) (PubMed).
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: "Differential regulation of synaptic and extrasynaptic α4 GABA(A) receptor populations by protein kinase A and protein kinase C in cultured cortical neurons." in: Neuropharmacology, Vol. 105, pp. 124-32, (2016) (PubMed).
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- GABRG2 (gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2))
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别名
- GABRG2
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背景
- Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990, Whiting et al., 1999, Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for alpha and beta subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma subunit is required for benzodiazepine modulation. It has recently been suggested that PKC regulates the sensitivity of GABAA alpha1beta2gamma2 receptors to ethanol and benzodiazepines through phosphorylation of serine 327 in the large intracellular loop of gamma2 (Qi et al., 2007)
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分子量
- '45 kDa
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基因ID
- 29709
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UniProt
- P18508
抗原
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