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Dynamin 1 抗体 (pSer778)

DNM1 适用: 大鼠 WB 宿主: 绵羊 Polyclonal unconjugated
产品编号 ABIN361465
发货至: 中国
  • 抗原 See all Dynamin 1 (DNM1) 抗体
    Dynamin 1 (DNM1)
    抗原表位
    • 31
    • 31
    • 15
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer778
    适用
    • 106
    • 49
    • 46
    • 9
    • 8
    • 7
    • 3
    • 2
    • 2
    • 2
    • 1
    大鼠
    宿主
    • 99
    • 9
    • 2
    绵羊
    克隆类型
    • 107
    • 4
    多克隆
    标记
    • 50
    • 6
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    This Dynamin 1 antibody is un-conjugated
    应用范围
    • 88
    • 39
    • 39
    • 37
    • 20
    • 14
    • 13
    • 6
    • 6
    • 4
    • 2
    • 1
    • 1
    Western Blotting (WB)
    特异性
    Specific for the ~95k dynamin protein phosphorylated at Ser778. Labels the purified protein phosphorylated in vitro by cdk5 but not by PKC. Does not cross react with other purified substrates of cdk5 (e.g. amphiphysin and synapsin). Immunolabeling is blocked by (-phosphatase treatment.
    交叉反应
    大鼠
    预测反应
    bovine, canine, chicken, human, mouse
    纯化方法
    Antigen Affinity Purified from Pooled Serum
    免疫原
    Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser778 conjugated to KLH
    Top Product
    Discover our top product DNM1 Primary Antibody
  • 应用备注
    Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.
    储存条件
    -20 °C
  • 抗原
    Dynamin 1 (DNM1)
    别名
    DNM1 (DNM1 产品)
    别名
    DNM antibody, Dnm antibody, AI838169 antibody, Ftfl antibody, mKIAA4093 antibody, dnm antibody, DNM1 antibody, Dnm1 antibody, dnm1 antibody, si:dkey-246l19.2 antibody, dynamin 1 antibody, dynamin-1 antibody, dynamin 1a antibody, DNM1 antibody, Dnm1 antibody, BACOIKO008_37 antibody, PTRG_07818 antibody, PTRG_08097 antibody, dnm1 antibody, LOC100168088 antibody, LOC100199205 antibody, dnm1a antibody
    背景
    Dynamin is a member of a group of nerve terminal proteins called dephosphins that regulate synaptic vesicle endocytosis (Cousin et al., 2001, Graham et al., 2002, Tsuboi et al., 2002). Cyclin dependent protein kinase 5 phosphorylates dynamin at Ser774 and Ser778 that are the phosphorylation sites on dynamin phosphorylated in vivo (Tan et al., 2003). Phosphorylation of these sites on dynamin is thought to play a key role in synaptic vesicle trafficking. Anti-Phospho Ser778 Dynamin Western blot of rat hippocampal lysate stimulated with forskolin showing specific immunolabeling of the ~95k dynamin phosphorylated at Ser778 (Control). The phosphospecificity of this labeling is shown in the second lane (lambda-phosphatase: (-Ptase). The blot is identical to the control except that it was incubated in (-Ptase (1200 units for 30 min) before being exposed to the Anti-Ser778 dynamin. The immunolabeling is completely eliminated by treatment with (-Ptase.
    分子量
    '95 kDa
    基因ID
    140694
    UniProt
    P21575
    途径
    Toll-Like Receptors Cascades, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling
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