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GABRA1 抗体 (N-Term)

Name: GABRA1 抗体 (N-Term)
Brand: antibodies-online
SKU: ABIN361435
Availability: OutOfStock

This anti-GABRA1 antibody is a 兔多克隆 antibody detecting GABRA1 in WB. Suitable for 大鼠. This Primary Antibody has been cited in 1 publication.

Western blots of mouse forebrain lysates from Wild Type (Control) and a1-knockout (a1-K/O) animals showing specific immunolabeling of the ~51k a1-subunit of the GABAA-R. (GABRA1 抗体 (N-Term))

Western blot of mouse forebrain lysates from Wild Type (WT) and α1-knockout (K/O) animals showing specific immunolabeling of the ~51 kDa α1-subunit of the GABAA-R. (GABRA1 抗体 (N-Term))

2 images

(1 reference)

产品编号 ABIN361435

发货至: 中国

Quick Overview for GABRA1 抗体 (N-Term) (ABIN361435)

抗原

See all GABRA1 抗体

GABRA1 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1))

适用

大鼠

宿主

兔

克隆类型

多克隆

标记

This GABRA1 antibody is un-conjugated

应用范围

Western Blotting (WB)

Discover our top product GABRA1 Primary Antibody

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N-Term

特异性

Specific for the ~51k a1-subunit of the GABAA receptor in Western blots of rat brain. Labeling is absent in alpha1-subunit knockout animals.

交叉反应

小鼠, 大鼠

预测反应

bovine, canine, human, non-human primate

纯化方法

Antigen Affinity Purified

免疫原

Synthetic peptide corresponding to amino acid residues from the N-terminal region conjugated to KLH
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1) (AA 15-34) antibody
GABRA1 适用: 大鼠 WB, ICC, IF, AA 宿主: 小鼠 Monoclonal N151-3 (Formerly S151-3) unconjugated

anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1) (AA 350-385) antibody
GABRA1 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S399-19 unconjugated

anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1) (AA 15-34) antibody (HRP)
GABRA1 适用: 大鼠 WB, ICC, IF, AA 宿主: 小鼠 Monoclonal N151-3 (Formerly S151-3) HRP

anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1) (AA 350-385) antibody (HRP)
GABRA1 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S399-19 HRP

anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1) (AA 15-34) antibody (FITC)
GABRA1 适用: 大鼠 WB, ICC, IF, AA 宿主: 小鼠 Monoclonal N151-3 (Formerly S151-3) FITC

anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1) (AA 350-385) antibody (FITC)
GABRA1 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S399-19 FITC

anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1) (AA 15-34) antibody (Biotin)
GABRA1 适用: 大鼠 WB, ICC, IF, AA 宿主: 小鼠 Monoclonal N151-3 (Formerly S151-3) Biotin

anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1) (AA 350-385) antibody (Biotin)
GABRA1 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S399-19 Biotin

anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1) (AA 15-34) antibody (PE)
GABRA1 适用: 大鼠 WB, ICC, IF, AA 宿主: 小鼠 Monoclonal N151-3 (Formerly S151-3) PE

anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1) (AA 350-385) antibody (PE)
GABRA1 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S399-19 PE

应用备注

Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.

限制

仅限研究用
状态

Liquid

缓冲液

100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

储存条件

-20 °C
Agoglia, Zhu, Ying, Sidhu, Natividad, Wolfe, Buczynski, Contet, Parsons, Roberto, Herman: "Corticotropin-Releasing Factor Receptor-1 Neurons in the Lateral Amygdala Display Selective Sensitivity to Acute and Chronic Ethanol Exposure." in: eNeuro, Vol. 7, Issue 2, (2020) (PubMed).
抗原

GABRA1 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1))

别名

GABRA1

背景

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six (s, four (s and four (s, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990, Whiting et al., 1999, Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for (- and (-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a (-subunit is required for benzo-diazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different (-subunits of the receptor (McKernan et al., 2000, Mehta and Ticku, 1998, Ogris et al., 2004, Pöltl et al., 2003). Anti-GABAA Receptor, a1-Subunit Western blot of mouse forebrain lysates from Wild Type (Control) and a1-knockout (a1-K/O) animals showing specific immunolabeling of the ~51k a1-subunit of the GABAA-R. The labeling was absent from a lysate prepared from a1-knockout animals.

分子量

'51 kDa

基因ID

29705

UniProt

P62813