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Tyrosine Hydroxylase 抗体

TH 适用: 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN361413
发货至: 中国
  • 抗原 See all Tyrosine Hydroxylase (TH) 抗体
    Tyrosine Hydroxylase (TH)
    适用
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    大鼠
    宿主
    • 107
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    克隆类型
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    多克隆
    标记
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    This Tyrosine Hydroxylase antibody is un-conjugated
    应用范围
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    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
    特异性
    Specific for the ~60k tyrosine hydroxylase protein.
    交叉反应
    哺乳动物
    纯化方法
    Antigen Affinity Purified from Pooled Serum
    免疫原
    SDS-denatured, native rat tyrosine hydroxylase purified from pheochromocytoma
    Top Product
    Discover our top product TH Primary Antibody
  • 应用备注
    Recommended Dilution: WB: 1:1000 IF (frozen sections, Xu et al., 1998): 1:1000 IHC (frozen sections, Xu et al., 1998): 1:1000 Quality Control: Western blots performed on each lot.
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.
    储存条件
    -20 °C
  • Sanyal, Dutta, Camara, Chandran, Koller, Watson, Sengupta, Ysselstein, Montenegro, Cannon, Rochet, Mattoo: "Alpha-Synuclein Is a Target of Fic-Mediated Adenylylation/AMPylation: Possible Implications for Parkinson's Disease." in: Journal of molecular biology, Vol. 431, Issue 12, pp. 2266-2282, (2020) (PubMed).

    Brindley, Bauer, Walker, Quinlan, Carneiro, Sze, Blakely, Currie: "Adrenal serotonin derives from accumulation by the antidepressant-sensitive serotonin transporter." in: Pharmacological research, Vol. 140, pp. 56-66, (2019) (PubMed).

    de Rus Jacquet, Timmers, Ma, Thieme, McCabe, Vest, Lila, Rochet: "Lumbee traditional medicine: Neuroprotective activities of medicinal plants used to treat Parkinson's disease-related symptoms." in: Journal of ethnopharmacology, Vol. 206, pp. 408-425, (2018) (PubMed).

    de Rus Jacquet, Tambe, Ma, McCabe, Vest, Rochet: "Pikuni-Blackfeet traditional medicine: Neuroprotective activities of medicinal plants used to treat Parkinson's disease-related symptoms." in: Journal of ethnopharmacology, Vol. 206, pp. 393-407, (2018) (PubMed).

    Salvatore, Waymire, Haycock: "Depolarization-stimulated catecholamine biosynthesis: involvement of protein kinases and tyrosine hydroxylase phosphorylation sites in situ." in: Journal of neurochemistry, Vol. 79, Issue 2, pp. 349-60, (2001) (PubMed).

  • 抗原
    Tyrosine Hydroxylase (TH)
    别名
    Tyrosine Hydroxylase (TH 产品)
    别名
    DYT14 antibody, DYT5b antibody, TYH antibody, The antibody, CG10118 antibody, DH65B antibody, DTH antibody, Dmel\\CG10118 antibody, Pale antibody, Ple antibody, TH antibody, Th antibody, VII antibody, dTH1 antibody, dTH65B antibody, pale/ple antibody, th antibody, dyt14 antibody, dyt5b antibody, tyh antibody, tyrosine hydroxylase antibody, pale antibody, tyrosine 3-monooxygenase antibody, tyrosine hydroxylase S homeolog antibody, TH antibody, Th antibody, ple antibody, th antibody, th.S antibody, LOC100008895 antibody
    背景
    Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines dopamine and norepinephrine. TH antibodies can therefore be used as markers for dopaminergic and noradrenergic neurons in a variety of applications including depression, schizophrenia, Parkinson’s disease and drug abuse (Kish et al., 2001, Zhu et al., 2000, Zhu et al., 1999). TH antibodies can also be used to explore basic mechanisms of dopamine and norepinephrine signaling (Witkovsky et al., 2000, Salvatore et al., 2001, Dunkley et al., 2004). Anti-Tyrosine Hydroxylase Western blot of 10 ug of rat caudate lysate showing specific immunolabeling of the ~60k TH protein.
    分子量
    '60 kDa
    基因ID
    25085
    UniProt
    P04177
    途径
    Dopaminergic Neurogenesis, Response to Water Deprivation, Sensory Perception of Sound, Carbohydrate Homeostasis, Feeding Behaviour
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