Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.
限制
仅限研究用
状态
Liquid
缓冲液
100 μL in 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.
储存条件
-20 °C
抗原
THRA
(Thyroid Hormone Receptor, alpha (THRA))
别名
THRA
背景
Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005, Chan and Kilby, 2000). Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors TRa1, TRa2, TR 1 and TR 2. TRa1, TR 1 and TR 2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005). Anti-Thyroid Hormone Receptor, a1/a2-Isotype Western blot of hippocampal lysate showing specific immunolabeling of the ~50k TR-a1 and the ~58k TR-a2 protein.