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GFAP 抗体

GFAP 适用: Cow WB, IF 宿主: 小鸡 Polyclonal unconjugated
产品编号 ABIN361379
发货至: 中国
  • 抗原 See all GFAP 抗体
    GFAP (Glial Fibrillary Acidic Protein (GFAP))
    适用
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    Cow
    宿主
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    小鸡
    克隆类型
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    多克隆
    标记
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    This GFAP antibody is un-conjugated
    应用范围
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    Western Blotting (WB), Immunofluorescence (IF)
    特异性
    Specific for the ~50kDa GFAP protein. A lower band at ~45kDa is a proteolytic fragment derived from the GFAP molecule. It is expected that the antibody will react with other mammalian tissues.
    交叉反应
    大鼠
    预测反应
    human, mouse
    纯化方法
    Total IgY fraction
    免疫原
    Recombinant and purified bovine GFAP
    Top Product
    Discover our top product GFAP Primary Antibody
  • 应用备注
    Recommended Dilution: WB: 1:10,000 IF: 1:1,000 Quality Control: Western blots performed on each lot.
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    total IgY fraction in PBS + 10 mM Sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
  • Levenga, Wong, Milstead, Keller, LaPlante, Hoeffer: "AKT isoforms have distinct hippocampal expression and roles in synaptic plasticity." in: eLife, Vol. 6, (2018) (PubMed).

  • 抗原
    GFAP (Glial Fibrillary Acidic Protein (GFAP))
    别名
    GFAP (GFAP 产品)
    别名
    GFAP antibody, AI836096 antibody, cb345 antibody, etID36982.3 antibody, gfapl antibody, wu:fb34h11 antibody, wu:fk42c12 antibody, xx:af506734 antibody, zgc:110485 antibody, glial fibrillary acidic protein antibody, GFAP antibody, LOC100136168 antibody, gfap antibody, Gfap antibody
    背景
    Glial Fibrillary Acidic Protein (GFAP) was discovered by Amico Bignami and co-workers as a major fibrous protein of multiple sclerosis plaques (1). It was subsequently found to be a member of the 10nm or intermediate filament (IF) family, specifically the IF family Class III, which also includes peripherin, desmin and vimentin. GFAP is strongly and specifically expressed in astrocytes and certain other astroglia in the CNS, in satellite cells, peripheral ganglia, and in non-myelinating Schwann cells in peripheral nerves. In many damage and disease states GFAP expression is heavily upregulated in astrocytes. In addition, neural stem cells frequently strongly express GFAP. Point mutations in the protein coding region of the GFAP gene lead to Alexander disease which is characterized by the presence of abnormal astrocytes containing GFAP protein aggregates known as Rosenthal fibers (2). Anti-GFAP Left: Western blot of rat cortex lysate showing specific immunolabeling of the ~ 50k GFAP protein. Right: Mixed cultures of neurons and glia stained with chicken anti-GFAP (red), and DNA (blue). Astrocytes stain strongly and specifically in a clearly filamentous fashion with this antibody.
    分子量
    '50 kDa
    基因ID
    281189
    UniProt
    Q28115
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