CGRP 抗体
Quick Overview for CGRP 抗体 (ABIN361373)
抗原
See all CGRP (CALCA) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- Specific for Calcitonin Gene Related Peptide. Also recognizes rat beta-CGRP and human alpha-CGRP (10-fold less sensitivity compared to rat alpha-CGRP). Suggested positive controls are dorsal root ganglia, pancreas and gut. Notes: This antibody is an excellent tool for immunohistochemistry and for multiple labeling immunofluorescence of peripheral tissue like stomach, intestine, pancreas, sensory ganglia, and all the regions of the body that are innervated by primary afferent neurons as well as central nervous tissue. It is expected that the antibody will react with most mammals.
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交叉反应
- 人, 大鼠
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预测反应
- most mammals
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纯化方法
- Protein G purified culture supernatant
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免疫原
- Purified rat alpha-CGRP
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亚型
- IgG2a
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anti-Calcitonin-Related Polypeptide alpha (CALCA) (AA 1-130) antibody
CALCA 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin-Related Polypeptide alpha (CALCA) (AA 1-141) antibodyCALCA 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin-Related Polypeptide alpha (CALCA) (AA 52-141) antibodyCALCA 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 4B10 unconjugated
anti-Calcitonin-Related Polypeptide alpha (CALCA) (AA 65-130) antibodyCALCA 适用: 人, 大鼠 ELISA, WB, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin-Related Polypeptide alpha (CALCA) (AA 1-134) antibodyCALCA 适用: 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin-Related Polypeptide alpha (CALCA) (Internal Region) antibodyCALCA 适用: 人, 大鼠, 小鼠 ELISA, WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin-Related Polypeptide alpha (CALCA) antibodyCALCA 适用: 人 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin-Related Polypeptide alpha (CALCA) (AA 85-116) antibodyCALCA 适用: 犬 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin-Related Polypeptide alpha (CALCA) antibodyCALCA 适用: 人 ELISA, IHC 宿主: 小鼠 Monoclonal 4G1H7 unconjugated
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应用备注
- Recommended Dilution: ICC: 1:50-1:100 Quality Control: ICC performed on each lot.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 100 μL in 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.
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储存条件
- -20 °C
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- CGRP (CALCA) (Calcitonin-Related Polypeptide alpha (CALCA))
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别名
- CALCA
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背景
- Calcitonin Gene Related Peptide [CGRP] is a 37 amino acid peptide and is the most potent endogenous vasodilator currently known (Brain et al.,1985). CGRP is primarily produced in nervous tissue, however, its receptors are expressed throughout the body. CGRP is also strongly implicated in the vasodilatory effect of endogenous cannabinoid anandamide in the brain. This effect was found to be antagonized by capsazepine. CGRP is also currently a major target of research in regards to factors effecting the onset of migraine headaches (Edvinsson L., 2003). CGRP antibodies have been used successfully in immunoneutralization (Wong et al., 1993)
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基因ID
- 24241
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UniProt
- P01256
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途径
- Hormone Activity, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Skeletal Muscle Fiber Development, Feeding Behaviour
抗原
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