Rho-related GTP-binding protein 抗体
(2 references)Quick Overview for Rho-related GTP-binding protein 抗体 (ABIN361366)
抗原
See all Rho-related GTP-binding protein (RhO (pan)) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
特异性
- Specific for the ~ 39k rhodopsin protein.
-
交叉反应
- Amphibian, 哺乳动物
-
纯化方法
- Protein G purified culture supernatant
-
免疫原
- Purified native bovine rhodopsin
-
亚型
- IgG1
-
-
anti-Rho-related GTP-binding protein (RhO (pan)) antibody
RhO (pan) 适用: 人, 大鼠, 小鼠 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-Rho-related GTP-binding protein (RhO (pan)) (C-Term) antibodyRhO (pan) 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Rho-related GTP-binding protein (RhO (pan)) antibodyRhO (pan) 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Rho-related GTP-binding protein (RhO (pan)) antibodyRhO (pan) 适用: 人 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Rho-related GTP-binding protein (RhO (pan)) (Internal Region) antibodyRhO (pan) 适用: 人 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-Rho-related GTP-binding protein (RhO (pan)) (AA 62-93) antibodyRhO (pan) 适用: 斑马鱼 WB 宿主: 兔 Polyclonal RB52315 unconjugated
anti-Rho-related GTP-binding protein (RhO (pan)) antibodyRhO (pan) 适用: 大鼠, 小鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Rho-related GTP-binding protein (RhO (pan)) (AA 310-339), (C-Term) antibodyRhO (pan) 适用: 人, 大鼠, 小鼠 WB 宿主: 兔 Polyclonal RB36659 unconjugated
-
-
应用备注
- Recommended Dilution: WB: 1:1000 IHC: 1:100 Quality Control: Western blots performed on each lot.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- 100 μL in 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.
-
储存条件
- -20 °C
-
-
-
: "Neonatal disease environment limits the efficacy of retinal transplantation in the LCA8 mouse model." in: BMC ophthalmology, Vol. 16, Issue 1, pp. 193, (2017) (PubMed).
: "Yap is essential for retinal progenitor cell cycle progression and RPE cell fate acquisition in the developing mouse eye." in: Developmental biology, Vol. 419, Issue 2, pp. 336-347, (2017) (PubMed).
-
: "Neonatal disease environment limits the efficacy of retinal transplantation in the LCA8 mouse model." in: BMC ophthalmology, Vol. 16, Issue 1, pp. 193, (2017) (PubMed).
-
- Rho-related GTP-binding protein (RhO (pan))
-
别名
- RHO
-
物质类
- Chemical
-
背景
- Rhodopsin is a photoreceptor protein found in retinal rods. It is a complex formed by the binding of retinaldehyde, the oxidized form of retinol, to the protein opsin and undergoes a series of complex reactions in response to visible light resulting in the transmission of nerve impulses to the brain. Mutation of the rhodopsin gene is a major contributor to various retinopathies such as retinitis pigmentosa. The disease-causing protein generally aggregates with ubiquitin in inclusion bodies, disrupts the intermediate filament network and impairs the ability of the cell to degrade non-functioning proteins which leads to photoreceptor apoptosis (Berson et al., 1991). Other mutations on rhodopsin lead to X-linked congenital stationary night blindness, mainly due to constitutive activation, when the mutations occur around the chromophore binding pocket of rhodopsin (Dryja et al.,1993). Several other pathological states relating to rhodopsin have been discovered including poor post-Golgi trafficking, dysregulative activation, rod outer segment instability and arrestin binding. Anti-Rhodopsin Immunohistochemical staining of mouse retinal section showing specific immunolabeling of the rhodopsin protein in the rod spherules. Photo courtesy of Mary Raven, University of California, Santa Barbara, CA.
-
分子量
- '39 kDa
-
基因ID
- 509933
-
UniProt
- P02699
抗原
-
