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4-Hydroxy-2-Hexenal (4-HHE) 抗体

Cited in 2+ publications. The 小鼠 单克隆 anti-4-Hydroxy-2-Hexenal (4-HHE) antibody (Clone HHE53) (ABIN361275) specifically detects 4-Hydroxy-2-Hexenal (4-HHE) in IHC.
产品编号 ABIN361275
发货至: 中国
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Quick Overview for 4-Hydroxy-2-Hexenal (4-HHE) 抗体 (ABIN361275)

抗原

4-Hydroxy-2-Hexenal (4-HHE)

宿主

  • 11
小鼠

克隆类型

  • 11
单克隆

标记

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非结合性

应用范围

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Immunohistochemistry (IHC)

克隆位点

HHE53
  • 特异性

    Specific for HHE-modified protein (especially HHE-His Michael adduct)

    免疫原

    HHE-modified keyhole-lympet hemocyanine

    亚型

    IgG1 kappa
  • 应用备注

    Immunohistochemistry: It is recommended that the antibody be tried at 0.5-1.0 micro g/mL on paraformaldehyde fixed tissue.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Frozen in 10 mM PBS containing 0.1 % NaN3 and 0.1 % BSA

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C
  • Tanito, Elliott, Kotake, Anderson: "Protein modifications by 4-hydroxynonenal and 4-hydroxyhexenal in light-exposed rat retina." in: Investigative ophthalmology & visual science, Vol. 46, Issue 10, pp. 3859-68, (2005) (PubMed).

    Yamada, Funada, Shibata, Kobayashi, Kawai, Tatsuda, Furuhata, Uchida: "Protein-bound 4-hydroxy-2-hexenal as a marker of oxidized n-3 polyunsaturated fatty acids." in: Journal of lipid research, Vol. 45, Issue 4, pp. 626-34, (2004) (PubMed).

  • 抗原

    4-Hydroxy-2-Hexenal (4-HHE)

    物质类

    Chemical

    背景

    4-hydroxy-2-alkenal is one of the major lipid peroxidation products, and shows many biological effects such as high toxicity to cells. Among them, 4-hydroxy-2-hexenal (HHE) is an aldehyde formed during peroxidation of n-3 fatty acids such as docosahexaenoic acid. HHE is highly reactive aldehyde and reacts with histidine residue of protein to form Michael-addition type adducts. This antibody is specific for HHE-histidine Michael adduct (HHE-His) and enable to detect HHE-His in the tissue samples.
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