LEFTY1 抗体
Our Local Distributor
北京 101111
Quick Overview for LEFTY1 抗体 (ABIN360926)
抗原
See all LEFTY1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
特异性
- This antibody detects Lefty-1.
-
纯化方法
- Protein A/G affinity chromatography
-
免疫原
- Recombinant protein of Lefty-1
-
亚型
- IgG2
-
-
anti-Left-Right Determination Factor 1 (LEFTY1) (AA 78-361) antibody
LEFTY1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Left-Right Determination Factor 1 (LEFTY1) (AA 1-366) antibodyLEFTY1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2E10 unconjugated
anti-Left-Right Determination Factor 1 (LEFTY1) (AA 1-366) antibodyLEFTY1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Left-Right Determination Factor 1 (LEFTY1) (N-Term) antibodyLEFTY1 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Left-Right Determination Factor 1 (LEFTY1) (Internal Region) antibodyLEFTY1 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Left-Right Determination Factor 1 (LEFTY1) (C-Term) antibodyLEFTY1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Left-Right Determination Factor 1 (LEFTY1) (AA 283-314), (C-Term) antibodyLEFTY1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB14580 unconjugated
anti-Left-Right Determination Factor 1 (LEFTY1) (AA 43-364) antibodyLEFTY1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Left-Right Determination Factor 1 (LEFTY1) (AA 169-368) antibodyLEFTY1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Left-Right Determination Factor 1 (LEFTY1) (AA 1-366) antibodyLEFTY1 适用: 人 IP, ELISA 宿主: 小鼠 Monoclonal 4D7 unconjugated
-
-
应用备注
-
Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
-
-
-
溶解方式
- Restore with 200 μL sterile PBS and the final concentration is 500 μg/mL.
-
注意事项
- Avoid repeated freezing and thawing.
-
储存条件
- 4 °C/-20 °C
-
储存方法
- Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
-
-
- LEFTY1 (Left-Right Determination Factor 1 (LEFTY1))
-
别名
- LEFTY1
-
背景
- During vertebrate embryogenesis, a left right axis is established. Secreted growth factors of the TGF beta family, including gene products derived from nodal, lefty 1 and lefty 2, play crucial roles in establishing left right asymmetries. TGF beta (Transforming growth factor beta) is a pleiotropic cytokine that regulates growth and differentiation of diverse types of cells. TGF beta actions are directed by ligand induced activation of TGF beta receptors. Complexes formed move into the nucleus, where they act as components of a transcriptional complex. Lefty, a novel member of the TGF beta superfamily, inhibits TGF beta signaling. Lefty acts to inhibit phosphorylation of Smad2 following activation of the TGF beta receptor. Lefty also inhibits events downstream from R Smad phosphorylation. Lefty provides a repressed state of TGF beta responsive genes. The Lefty family is comprised of Lefty 1 and Lefty 2 in mouse, and Lefty A and Lefty B in humans. Members of the TGF beta superfamily require processing for their activation. Cleavage is therefore an essential step for Lefty activation. Lefty is synthesized as a large inactive precursor (41 Kda) that must be endoproteolytically processed to release the bioactive polypeptide (28 kDa and 34 kDa forms). The 28 kDa form induces MAPK activity.Synonyms: LEFTB, LEFTY1, LEFTYB, Left-right determination factor 1, Left-right determination factor B, Protein lefty-1, Protein lefty-B
-
基因ID
- 13590
-
NCBI登录号
- NP_034224
-
UniProt
- Q64280
抗原
-
