IL1RL1 抗体 (Extracellular Domain)
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Quick Overview for IL1RL1 抗体 (Extracellular Domain) (ABIN360904)
抗原
See all IL1RL1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- Extracellular Domain
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特异性
- This antibody detects IL-1 R4.
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纯化方法
- Protein A/G Affinity Chromatography
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过滤
- 0.2 μm filtered
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免疫原
- Purified Mouse Recombinant IL-1 R4 extracellular doamin
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亚型
- IgG2
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应用备注
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Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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溶解方式
- Restore with 200 μL sterile PBS and the final concentration is 500 μg/mL.
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缓冲液
- Lyophilized from a 0.2 μm filtered solution in PBS
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- IL1RL1 (Interleukin 1 Receptor-Like 1 (IL1RL1))
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别名
- IL1RL1 / ST2
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背景
- ST2 is a member of the Toll-Interleukin 1 receptor (TIR) superfamily, expressed by mast cells and TH2 helper cells, but not by TH1 effector cells. The majority of TIR superfamily members, which includes the Interleukin-1 receptor (IL-1R1), Toll-like receptors (TLRs) and the cytosolic adaptor proteins MyD88, TIRAP, Trif and TRAM, initiate innate immunity through the ultimate activation of the transcription factor NF-kappaB and are inducers of the inflammatory response. In contrast ST2, which itself is unable to activate NF-kappaB, has been identified as a negative regulator of IL-1R1 and TLR4 signaling by sequestering MyD88 and TIRAP, in line with its role as a crucial receptor in TH2-cell mediated responses.Synonyms: DER4, FIT-1, Homolog of mouse growth stimulation-expressed, Interleukin-1 receptor-like 1, MGC32623
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基因ID
- 17082
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NCBI登录号
- NP_001020773
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UniProt
- P14719
抗原
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