ARTN 抗体
Quick Overview for ARTN 抗体 (ABIN360873)
抗原
See all ARTN 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- This antibody detects Mouse Artemin.
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交叉反应 （详细）
- Species reactivity (tested):Mouse.
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纯化方法
- Affinity Chromatography on Protein A/G.
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免疫原
- Mouse Recombinant Artemin.
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亚型
- IgG2
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anti-Artemin (ARTN) (AA 101-150) antibody
ARTN 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Artemin (ARTN) (AA 101-170) antibodyARTN 适用: 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Artemin (ARTN) (AA 108-220) antibodyARTN 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Artemin (ARTN) (AA 112-224) antibodyARTN 适用: 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Artemin (ARTN) antibodyARTN 适用: 人, 大鼠, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Artemin (ARTN) (Internal Region) antibodyVerified ARTN 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Artemin (ARTN) antibodyARTN 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Artemin (ARTN) (AA 112-224) antibodyARTN 适用: 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western Blot: 1/500-1/1000. Immunohistochemistry on Frozen Sections: 1/50-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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溶解方式
- Restore with 200 μL sterile PBS (final concentration = 500 μg/mL).
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缓冲液
- 0.2 μm filtered PBS solution
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储存液
- Without preservative
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- ARTN (Artemin (ARTN))
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别名
- Artemin
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背景
- Artemin is a member of the Glia Cel-lDerived Neurotrophic factor (GDNF) family ligands, which include GDNF, Persephin, Artemin, and Neurturin. GDNF family ligands are distant members of the Transforming Growth Factor β (TGFβ) superfamily. Similar to other TGFβ family proteins, Artemin is synthesized as a large precursor protein that is cleaved at the dibasic cleavage site (RXXR) to release the carboxyterminal domain. The carboxy terminal domain of Artemin contains the characteristic seven conserved cysteine residues necessary for the formation of the cysteine-knot and the single interchain disulfide bond. Biologically active Artemin is a disulfide-linked homodimer of the carboxyterminal 113 amino acid residues. Mature mouse Artemin shares 88.5 % amino acid sequence similarity with human Artemin. Mature Artemin also shares approximately 40 % amino acid sequence identity with the other three members of the GDNF family ligands. Bioactivities of all GDNF family ligands are mediated through a receptor complex composed of a high affinity ligand binding component (GFRα1GFRα4) and a common signaling component, cRET (receptor tyrosine kinase). Artemin prefers to bind to GFRα3 and activites the GFRα3RET. However, in the presence of RET, it can bind to GFRα1 as well. Artemin has been shown to promote the survival and growth of various peripheral and central neurons, including sympathetic and dopaminergic neurons. It may also play an important role in the development of sympathetic neurons and several organs.Synonyms: ARTN, EVN, Enovin, Neublastin
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分子量
- 24 kDa.
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基因ID
- 11876
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NCBI登录号
- NP_033841
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UniProt
- Q9Z0L2
抗原
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