LDLRAP1 抗体 (C-Term)
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北京 101111
Quick Overview for LDLRAP1 抗体 (C-Term) (ABIN360441)
抗原
See all LDLRAP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- This antibody reacts to ARH (LDLRAP1).
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纯化方法
- Protein A column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
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免疫原
- This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human LDLRAP1.
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亚型
- Ig Fraction
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anti-Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) (AA 1-263) antibody
LDLRAP1 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 4G4-D5 unconjugated
anti-Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) (AA 1-308) antibodyLDLRAP1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) (AA 1-264) antibodyLDLRAP1 适用: 人 WB, IHC, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 4G4-D5 unconjugated
anti-Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) antibodyLDLRAP1 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) (N-Term) antibodyVerified LDLRAP1 适用: 人 ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) (AA 59-308) antibodyLDLRAP1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) (AA 59-308) antibodyLDLRAP1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) antibodyLDLRAP1 适用: 人, 犬 WB 宿主: 小鼠 Monoclonal 7A5 unconjugated
anti-Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) (AA 35-84) antibodyLDLRAP1 适用: 人, 犬, Cow, 兔, 马, Pig, 猴, 小鸡, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) (AA 277-306), (C-Term) antibodyLDLRAP1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB13027 unconjugated
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应用备注
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ELISA: 1/1,000. Western blotting: 1/50 - 1/100. Immunohistochemistry: 1/50.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.25 mg/mL
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缓冲液
- PBS with 0.09 % (W/V) sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
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- LDLRAP1 (Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1))
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别名
- LDLRAP1
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背景
- LDLRAP1 is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. This adapter protein is required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). LDLRAP1 may be required for LDL binding and internalization but not for receptor clustering in coated pits. This protein may facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits, and may also be involved in the internalization of other LDLR family members. Mutations in the LDLRAP1 gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia.Synonyms: ARH, Autosomal recessive hypercholesterolemia protein, LDLRAP1, Low density lipoprotein receptor adapter protein 1
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基因ID
- 26119, 9606
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UniProt
- Q5SW96
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途径
- Lipid Metabolism
抗原
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