MLK4 抗体 (N-Term)
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Quick Overview for MLK4 抗体 (N-Term) (ABIN360429)
抗原
See all MLK4 (KIAA1804) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- This antibody recognizes MLK4 (N-term). Other species not tested.
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纯化方法
- Protein A column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
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免疫原
- This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human MLK4.
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亚型
- Ig Fraction
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anti-Mitogen-Activated Protein Kinase Kinase Kinase MLK4 (KIAA1804) antibody
KIAA1804 适用: 人 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase MLK4 (KIAA1804) (AA 640-794) antibodyKIAA1804 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase MLK4 (KIAA1804) (AA 33-62), (N-Term) antibodyKIAA1804 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB12543 unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase MLK4 (KIAA1804) (AA 566-593) antibodyKIAA1804 适用: 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 1/1,000 . Western blotting: 1/50 - 1/100. Immunohistochemistry: 1/10 - 1/50.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.25 mg/mL
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缓冲液
- PBS, 0.09 % (W/V) Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
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- MLK4 (KIAA1804) (Mitogen-Activated Protein Kinase Kinase Kinase MLK4 (KIAA1804))
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别名
- MLK4
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背景
- Mixed-lineage kinases (MLKs) function as mitogen-activated protein kinase kinase kinases (MAP3Ks), activating the p38 and JNK signaling cascades. Systematic mutational analyses of tyrosine kinases reveal that a minimum of 30 % of colorectal cancer contain at least one mutation in the tyrosine kinases, sampling of colorect cancer cells suggest an important role of MLK4 in this process. Function: Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.Synonyms: KIAA1804, MLK4, Mitogen-activated protein kinase kinase kinase
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分子量
- 113957 Da
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基因ID
- 84451, 9606
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UniProt
- Q5TCX8
抗原
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