PKD2 抗体 (C-Term)
Quick Overview for PKD2 抗体 (C-Term) (ABIN360330)
抗原
See all PKD2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- This antibody recognizes Protein Kinase D2 (PKD2).
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交叉反应 （详细）
- Species reactivity (tested):Human.
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纯化方法
- Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
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免疫原
- This PKC-D2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of Human PKD2. Genename: PRKD2
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亚型
- Ig Fraction
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anti-Protein Kinase D2 (PKD2) antibody
PKD2 适用: 人 WB, IF, IHC (p), IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase D2 (PKD2) (AA 1-110) antibodyPKD2 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 2E4 unconjugated
anti-Protein Kinase D2 (PKD2) antibodyPKD2 适用: 人, 大鼠, 猴, 犬 WB, IF, FACS 宿主: 小鼠 Monoclonal 3F7 unconjugated
anti-Protein Kinase D2 (PKD2) (AA 829-878) antibodyPKD2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase D2 (PKD2) (Internal Region) antibodyPKD2 适用: 人, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase D2 (PKD2) (pSer876) antibodyPKD2 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase D2 (PKD2) (N-Term) antibodyPKD2 适用: 人, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase D2 (PKD2) antibodyPKD2 适用: 人, 大鼠, 猴, 犬 WB, IHC, IF, FACS 宿主: 小鼠 Monoclonal 5G1 unconjugated
anti-Protein Kinase D2 (PKD2) (AA 556-590) antibodyPKD2 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB56308 unconjugated
anti-Protein Kinase D2 (PKD2) (C-Term), (pSer876) antibodyPKD2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 1/1,000. Western blotting: 1/100-1/500. Immunohistochemistry on Paraffin Sections: 1/50-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.25 mg/mL
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缓冲液
- PBS with 0.09 % (W/V) Sodium Azide as preservative.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
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- PKD2 (Protein Kinase D2 (PKD2))
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别名
- PRKD2 / PKD2
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背景
- PKD2, a member of the polycystin family, functions as a calcium permeable cation channel. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis. PKD2 interacts with PKD1, potentially through the C-terminal region. PKD1 requires the presence of PKD2 for stable expression. PKD2 also interacts with CD2AP. This protein is strongly expressed in ovary, fetal and adult kidney, testis, and small intestine, but is not detected in peripheral leukocytes. Defects in PKD2 are the cause of autosomal dominant polycystic kidney disease type II (ADPKD-2) which represent approximately 15 % of cases of autosomal dominant polycystic kidney disease, a common autosomal dominant genetic disease affecting about 1 out 1000 individuals. ADPKD is characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occurs in the liver and other organs. All mutations, scattered between exons 1 and 11, result in a truncated PKD2 that lacks both the calcium-binding EF-hand domain and the two cytoplasmic domains required for the interaction of PKD2 with PKD1 and with itself. ADPKD type II is clinically milder than ADPKD type I, but it has a deleterious impact on overall life expectancy.Synonyms: HSPC187, PKC-D2, Serine/threonine-protein kinase D2, nPKC-D2
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基因ID
- 25865
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NCBI登录号
- NP_001073349
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UniProt
- Q9BZL6
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途径
- cAMP Metabolic Process, Maintenance of Protein Location, Negative Regulation of Transporter Activity
抗原
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