Prohibitin 2 抗体 (Tyr248)
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Quick Overview for Prohibitin 2 抗体 (Tyr248) (ABIN359504)
抗原
See all Prohibitin 2 (PHB2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Tyr248
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特异性
- This antibody detects PHB2.
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纯化方法
- Protein A column, followed by peptide affinity purification.
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免疫原
- This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide corresponding to amino acid residues surrounding Y248 of human PHB2.
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亚型
- Ig Fraction
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应用备注
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ELISA 1: 1,000. Western blot 1: 50 - 1: 100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.25 mg/mL
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缓冲液
- PBS with 0.09 % (W/V) sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
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- Prohibitin 2 (PHB2)
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别名
- Prohibitin-2
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背景
- PHB2 acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. It functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. It competes with NCOA1 for modulation of ER transcriptional activity and is probably involved in regulating mitochondrial respiration activity and in aging.Synonyms: B-cell receptor-associated protein BAP37, BAP, BAP37, D-prohibitin, PHB2, REA, Repressor of estrogen receptor activity
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分子量
- 33165 Da predicted from amino acid sequence. Theoretical pI: 9.83.
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基因ID
- 11331, 9606
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UniProt
- Q99623
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling
抗原
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