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Deoxyguanosine Kinase 抗体 (C-Term)

DGUOK 适用: 人, 小鼠 WB, EIA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN359186
发货至: 中国
  • 抗原 See all Deoxyguanosine Kinase (DGUOK) 抗体
    Deoxyguanosine Kinase (DGUOK)
    抗原表位
    • 10
    • 9
    • 7
    • 7
    • 5
    • 1
    • 1
    C-Term
    适用
    • 41
    • 11
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 小鼠
    宿主
    • 39
    • 2
    克隆类型
    • 39
    • 2
    多克隆
    标记
    • 17
    • 6
    • 5
    • 5
    • 4
    • 4
    This Deoxyguanosine Kinase antibody is un-conjugated
    应用范围
    • 34
    • 34
    • 4
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    特异性
    This antibody reacts to Deoxyguanosine Kinase (DGUOK).
    纯化方法
    Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
    免疫原
    This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human DGUOK.
    亚型
    Ig Fraction
    Top Product
    Discover our top product DGUOK Primary Antibody
  • 应用备注
    ELISA: 1/1,000. Western blotting: 1/100 - 1/500.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.25 mg/mL
    缓冲液
    PBS with 0.09 % (W/V) sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • 抗原
    Deoxyguanosine Kinase (DGUOK)
    别名
    Deoxyguanosine Kinase (DGUOK 产品)
    别名
    DGUOK antibody, zgc:86625 antibody, dgk antibody, DDBDRAFT_0218264 antibody, DDBDRAFT_0233982 antibody, DDB_0218264 antibody, DDB_0233982 antibody, MTDPS3 antibody, dGK antibody, dGK1 antibody, dGK2 antibody, dGK3 antibody, deoxyguanosine kinase antibody, deoxyguanosine kinase L homeolog antibody, DGUOK antibody, dguok antibody, dguok.L antibody, dgk antibody, Ccan_04750 antibody, Dguok antibody
    背景
    Mitochondrial deoxyguanosine kinase (DGUOK) is required for the phosphorylation of several deoxyribonucleosides and certain purine deoxykribonucleoside analogs widely employed as antiviral and chemotherapeutic agents. Purine deoxyribonucleoside analogs are extensively used in treatment of lymphoproliferative disorders. These compounds are administered as pro-drugs, and their efficiency is dependent on intracellular phosphorylation to the corresponding triphosphates. In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by 2 deoxyribonucleoside kinases: cytosolic deoxycytidine kinase (DCK) and mitochondrial deoxyguanosine kinase (DGUOK also known as DGK). DGUOK expression is ubiquitous, with highest levels in muscle, brain, liver and lymphoid tissues. Defects in DGUOK are a cause of mitochondrial DNA depletion syndrome (MDS). MDS is a clinically heterogeneous group of disorders characterized by a reduction in mitochondrial DNA (mtDNA) copy number. Primary mtDNA depletion is inherited as an autosomal recessive trait and may affect single organs, typically muscle or liver, or multiple tissues. Mitochondrial DNA depletion syndromes are phenotypically heterogeneous, autosomal recessive disorders characterized by tissue-specific reduction in mtDNA copy number. Affected individuals with the hepatocerebral form of mtDNA depletion syndrome have early progressive liver failure and neurologic abnormalities, hypoglycemia, and increased lactate in body fluids.Synonyms: DGK, DGUOK
    基因ID
    1716, 9606
    UniProt
    Q16854
    途径
    Ribonucleoside Biosynthetic Process
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