Deoxyguanosine Kinase 抗体 (N-Term)
Quick Overview for Deoxyguanosine Kinase 抗体 (N-Term) (ABIN359185)
抗原
See all Deoxyguanosine Kinase (DGUOK) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- This antibody reacts to Deoxyguanosine Kinase (DGUOK).
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纯化方法
- Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
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免疫原
- This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human DGUOK.
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亚型
- Ig Fraction
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anti-Deoxyguanosine Kinase (DGUOK) (AA 1-89) antibody
DGUOK 适用: 人 ELISA, WB, RNAi 宿主: 小鼠 Monoclonal 3E9 unconjugated
anti-Deoxyguanosine Kinase (DGUOK) (AA 40-277) antibodyDGUOK 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Deoxyguanosine Kinase (DGUOK) antibodyDGUOK 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Deoxyguanosine Kinase (DGUOK) (C-Term) antibodyDGUOK 适用: 人, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Deoxyguanosine Kinase (DGUOK) (AA 40-277) antibodyDGUOK 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Deoxyguanosine Kinase (DGUOK) (AA 1-30), (N-Term) antibodyDGUOK 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB5277 unconjugated
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应用备注
- ELISA 1/1,000. Western blotting: 1/100 - 1/500.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.25 mg/mL
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缓冲液
- PBS with 0.09 % (W/V) sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
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- Deoxyguanosine Kinase (DGUOK)
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别名
- Deoxyguanosine Kinase
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背景
- Mitochondrial deoxyguanosine kinase (DGUOK) is required for the phosphorylation of several deoxyribonucleosides and certain purine deoxykribonucleoside analogs widely employed as antiviral and chemotherapeutic agents. Purine deoxyribonucleoside analogs are extensively used in treatment of lymphoproliferative disorders. These compounds are administered as pro-drugs, and their efficiency is dependent on intracellular phosphorylation to the corresponding triphosphates. In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by 2 deoxyribonucleoside kinases: cytosolic deoxycytidine kinase (DCK) and mitochondrial deoxyguanosine kinase (DGUOK also known as DGK). DGUOK expression is ubiquitous, with highest levels in muscle, brain, liver and lymphoid tissues. Defects in DGUOK are a cause of mitochondrial DNA depletion syndrome (MDS). MDS is a clinically heterogeneous group of disorders characterized by a reduction in mitochondrial DNA (mtDNA) copy number. Primary mtDNA depletion is inherited as an autosomal recessive trait and may affect single organs, typically muscle or liver, or multiple tissues. Mitochondrial DNA depletion syndromes are phenotypically heterogeneous, autosomal recessive disorders characterized by tissue-specific reduction in mtDNA copy number. Affected individuals with the hepatocerebral form of mtDNA depletion syndrome have early progressive liver failure and neurologic abnormalities, hypoglycemia, and increased lactate in body fluids.Synonyms: DGK, DGUOK
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基因ID
- 1716, 9606
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UniProt
- Q16854
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途径
- Ribonucleoside Biosynthetic Process
抗原
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