SNCA 抗体 (C-Term)
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北京 101111
Quick Overview for SNCA 抗体 (C-Term) (ABIN358993)
抗原
See all SNCA 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- This antibody reacts to Alpha-Synuclein.
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纯化方法
- Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
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免疫原
- This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide in the C-terminal region of human Alpha-synuclein that is specific for Alpha- synuclein isoform NACP140 not NACP112.
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亚型
- Ig Fraction
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anti-Synuclein, alpha (SNCA) (pSer129) antibody
SNCA 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (PerCP)SNCA 适用: 人 WB, ELISA, IHC, ICC 宿主: 兔 Monoclonal J18 PerCP
anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (PE)SNCA 适用: 人 WB, ELISA, IHC, ICC 宿主: 兔 Monoclonal J18 PE
anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (Atto 488)SNCA 适用: 人 WB, ELISA, IHC, ICC 宿主: 兔 Monoclonal J18 Atto 488
anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (Atto 390)SNCA 适用: 人 WB, ELISA, IHC, ICC 宿主: 兔 Monoclonal J18 Atto 390
anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (Atto 594)SNCA 适用: 人 WB, ELISA, IHC, ICC 宿主: 兔 Monoclonal J18 Atto 594
anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (Biotin)SNCA 适用: 人 WB, ELISA, IHC, ICC 宿主: 兔 Monoclonal J18 Biotin
anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (FITC)SNCA 适用: 人 WB, ELISA, IHC, ICC 宿主: 兔 Monoclonal J18 FITC
anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (APC)SNCA 适用: 人 WB, ELISA, IHC, ICC 宿主: 兔 Monoclonal J18 APC
anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (HRP)SNCA 适用: 人 WB, ELISA, IHC, ICC 宿主: 兔 Monoclonal J18 HRP
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应用备注
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ELISA: 1/1,000. Western blotting: 1/100 - 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.25 mg/mL
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缓冲液
- PBS with 0.09 % (W/V) sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
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- SNCA (Synuclein, alpha (SNCA))
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别名
- alpha-Synuclein / SNCA
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背景
- Alpha Synuclein is implicated in the regulation of dopamine release and transport. It is a soluble protein, expressed principally in the brain but also expressed in low concentrations in all tissues examined (except liver). In the nervous system, alpha Synuclein is primarily located at presynaptic terminals and is found membrane bound in dopaminergic neurons. It can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies), including Parkinson's Disease. Alpha Synuclein induces fibrillization of microtubule associated protein tau and reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase 3 activation. Alpha synuclein is a protein phosphorylated predominantly on serine residues. Two alternatively spliced transcripts of Alpha Synuclein have been identified. Additional splicing may be present but the full-length nature of these variants has not been determined. This variant (NACP140) is the longer transcript and encodes the longer isoform (NACP140). This antibody specific recognizing Alpha-synuclein isoform NACP140 not NACP112.Synonyms: NACP, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, PARK1
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基因ID
- 6622, 9606
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UniProt
- P37840
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途径
- Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity
抗原
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