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RAPTOR 抗体 (pSer863)

RAPTOR 适用: 人 EIA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN358426
发货至: 中国
  • 抗原 See all RAPTOR 抗体
    RAPTOR
    抗原表位
    • 15
    • 15
    • 15
    • 6
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer863
    适用
    • 62
    • 45
    • 25
    • 15
    • 1
    宿主
    • 62
    • 3
    克隆类型
    • 62
    • 3
    多克隆
    标记
    • 20
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This RAPTOR antibody is un-conjugated
    应用范围
    • 30
    • 26
    • 26
    • 26
    • 9
    • 8
    • 7
    • 6
    • 6
    • 3
    • 3
    • 3
    • 2
    Enzyme Immunoassay (EIA)
    特异性
    This antibody detects Raptor pSer863.
    纯化方法
    Protein A Chromatography followed by two-step phosphospecific peptide affinity purification.
    免疫原
    This antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S863 of human Raptor.
    亚型
    Ig Fraction
    Top Product
    Discover our top product RAPTOR Primary Antibody
  • 应用备注
    ELISA: 1/1,000. Dot Blot: 1/500.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.25 mg/mL
    缓冲液
    PBS with 0.09 % (W/V) Sodium Azide as preservative.
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • 抗原
    RAPTOR
    别名
    RAPTOR (RAPTOR 产品)
    别名
    KOG1 antibody, Mip1 antibody, 4932417H02Rik antibody, Rap antibody, Raptor antibody, mKIAA1303 antibody, RGD1311784 antibody, regulatory associated protein of MTOR complex 1 antibody, regulatory associated protein of MTOR, complex 1 antibody, RPTOR antibody, Rptor antibody
    背景
    Raptor participates in the FRAP1 pathway and associates in a near stoichiometric ratio with FRAP1 to form a nutrient-sensitive complex (NSC). It plays a pivotal role as a scaffold protein in the FRAP1-signaling pathway and this interaction is essential for the catalyzed phosphorylation of EIF4EBP1. It has a positive role in nutrient-stimulated signaling to the downstream effector RPS6KB1. Under nutrient-deprived conditions, raptor serves as a negative regulator of FRAP1 kinase activity. Regulation of the interaction with FRAP1 is a critical mechanism by which cells coordinate the rate of cell growth and maintenance of cell size with different environmental conditions.Synonyms: KIAA1303, P150 target of rapamycin TOR-scaffold protein, RPTOR, Regulatory-associated protein of mTOR
    分子量
    149038 Da
    基因ID
    57521, 9606
    UniProt
    Q8N122
    途径
    Warburg Effect
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