USP33 抗体 (C-Term)
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Quick Overview for USP33 抗体 (C-Term) (ABIN357591)
抗原
See all USP33 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- This antibody is specific to USP33/VDU1 (C-term).
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纯化方法
- Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
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免疫原
- This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human VDU1-II.
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亚型
- Ig Fraction
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anti-Ubiquitin Specific Peptidase 33 (USP33) (AA 327-426) antibody
USP33 适用: 人 ELISA, WB, IF, IP, IHC (p) 宿主: 小鼠 Monoclonal 5B5 unconjugated
anti-Ubiquitin Specific Peptidase 33 (USP33) (AA 290-400) antibodyUSP33 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 33 (USP33) antibodyUSP33 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 33 (USP33) (AA 251-550) antibodyUSP33 适用: 人 ELISA, WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 33 (USP33) (AA 327-427) antibodyUSP33 适用: 人 ELISA, WB, IHC, IF, IP, IHC (p) 宿主: 小鼠 Monoclonal 5B5 unconjugated
anti-Ubiquitin Specific Peptidase 33 (USP33) (Internal Region) antibodyUSP33 适用: 人, Cow, 犬, 兔, 马, Bat IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 33 (USP33) (AA 1-911) antibodyUSP33 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 33 (USP33) (AA 799-829) antibodyUSP33 适用: 人 ELISA, WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- ELISA: 1/1,000. Western Blot: 1/100-1/500.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.25 mg/mL
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缓冲液
- PBS with 0.09 % (W/V) Sodium Azide as preservative.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
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- USP33 (Ubiquitin Specific Peptidase 33 (USP33))
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别名
- USP33 / VDU1
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背景
- Type 2 iodothyronine deiodinase (D2) is an integral membrane selenoenzyme that stimulates the pro-hormone thyroxine (T4) and supplies the majority of the 3,5,3'-triiodothyronine (T3) essential for brain development.1 T4 catalysis accelerates selective conjugation to ubiquitin and thereby renders D2 inactive, a posttranslational feedback mechanism used to maintain acceptable T3 levels.2,3 Ub-D2 was the first recognized substrate for von Hippel?Lindau protein?interacting (pVHL-interacting) deubiquitinating enzyme-1 (VDU1).4 VDU proteins colocalize with D2 in the endoplasmic reticulum, and their coexpression provides D2 resistance to degradation. VDU1 expression is substantially upregulated in brown adipocytes by norepinephrine or cold exposure, further amplifying D2 activity. VDU1 and VDU2 are coexpressed with D2 in many human tissues, including brain, heart, and skeletal muscle, suggesting potential roles in neurological development, cardiac function, and energy management, in addition to thermal homeostasis.VDU1- or VDU2-catalyzed deubiquitination recycles inactive Ub-D2 to its active deubiquitinated form, circumventing the proteasomal degradation pathway. Thus, Ub-D2 can be either reactivated or degraded, with the balance between these two processes influenced by VDU activity.VDU1-catalyzed D2 deubiquitination may be an important participant in the adaptive mechanism that regulates thyroid hormone action. The reversible ubiquitination-dependent mechanism regulating D2 activity permits highly responsive control of thyroid hormone activation.5,6Synonyms: KIAA1097, Ubiquitin carboxyl-terminal hydrolase 33, Ubiquitin thioesterase 33, VHL-interacting deubiquitinating enzyme 1
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分子量
- 106752 Da
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基因ID
- 23032, 5874
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UniProt
- Q8TEY7
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途径
- Regulation of G-Protein Coupled Receptor Protein Signaling
抗原
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