EPS15 抗体 (C-Term)
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- 抗原 See all EPS15 抗体
- EPS15 (Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15))
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抗原表位
- C-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This EPS15 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Enzyme Immunoassay (EIA)
- 特异性
- This antibody is specific to EPS15 (C-term).
- 纯化方法
- Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
- 免疫原
- This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human EPS15.
- 亚型
- Ig Fraction
- Top Product
- Discover our top product EPS15 Primary Antibody
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anti-Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15) antibody
EPS15 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15) (pTyr849) antibodyEPS15 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15) (pTyr849) antibodyEPS15 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15) (pTyr849) antibodyEPS15 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15) (AA 794-843) antibodyEPS15 适用: 人, 小鼠, 大鼠, Pig, Cow, 马, 猴, 兔, 豚鼠, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15) (AA 2-88) antibodyEPS15 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15) (C-Term) antibodyEPS15 适用: 人, 小鼠, 大鼠, Pig, Cow, 马, 犬, 兔, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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ELISA: 1/1,000. Western Blot: 1/100-1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.25 mg/mL
- 缓冲液
- PBS with 0.09 % (W/V) Sodium Azide as preservative.
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
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- 抗原
- EPS15 (Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15))
- 别名
- AF1P / EPS15 (EPS15 产品)
- 别名
- AF-1P antibody, AF1P antibody, MLLT5 antibody, CG16932 antibody, Dmel\\CG16932 antibody, EH1 antibody, EPS-15 antibody, Eps15 antibody, anon-WO0118547.85 antibody, eps-15 antibody, eps15 antibody, i31 antibody, 2410112D09Rik antibody, RGD1307641 antibody, epidermal growth factor receptor pathway substrate 15 antibody, Epidermal growth factor receptor pathway substrate clone 15 antibody, hypothetical protein antibody, EPS15 antibody, Eps-15 antibody, eps15 antibody, Eps15 antibody, PGTG_06574 antibody
- 背景
- EPS15 is involved in cell growth regulation, possibly via the regulation of mitogenic signals and control of cell proliferation. EPS15 also participates in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Potential interaction partners include AP2A2, STN2, EPN1, and CRK via its SH3-binding sites. EPS15 is ubiquitously expressed. Phosphorylation on Tyr-849 is involved in the internalization of EGFR. EPS15 is not required for membrane translocation after EGF treatment or for targeting to coated pits, but essential for a subsequent step in EGFR endocytosis. This protein is involved in a t(1,11)(p32,q23) chromosomal translocation in acute leukemias causing fusion to the trithorax (MLL or HRX) gene product which contains DNA-binding motifs resulting in a rogue activator protein. Structurally, EPS15 contains 2 EF-hand calcium-binding domains, 3 EH domains, and 2 ubiquitin-interacting motif (UIM) repeats.Synonyms: Epidermal growth factor receptor substrate 15, Protein AF-1p
- 分子量
- 98673 Da
- 基因ID
- 2060, 5874
- UniProt
- P42566
- 途径
- EGFR Signaling Pathway, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, EGFR Downregulation
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