Osteocalcin 抗体 (N-Term)
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Quick Overview for Osteocalcin 抗体 (N-Term) (ABIN357367)
抗原
See all Osteocalcin (BGLAP) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 9-39, N-Term
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特异性
- This antibody detects Osteocalcin at N-term.
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交叉反应 （详细）
- Species reactivity (tested):Human.
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纯化方法
- Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
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免疫原
- Synthetic peptide KLH conjugated between 9~39 amino acids from the N-terminal region of Human Osteocalcin.
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亚型
- Ig Fraction
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anti-Osteocalcin (BGLAP) (AA 14-95) antibody
BGLAP 适用: 小鼠 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Osteocalcin (BGLAP) (AA 21-100) antibodyBGLAP 适用: 人, 大鼠, 小鼠, 犬 WB, ELISA, ICC, IHC (p), IHC (fro), IF (p), IF (cc) 宿主: 兔 Polyclonal unconjugated
anti-Osteocalcin (BGLAP) (AA 1-100) antibodyBGLAP 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Osteocalcin (BGLAP) (AA 52-100) antibodyBGLAP 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2D4 unconjugated
anti-Osteocalcin (BGLAP) (AA 21-80) antibodyBGLAP 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC (p), FACS, IHC (fro), IF (p), IF (cc) 宿主: 兔 Polyclonal unconjugated
anti-Osteocalcin (BGLAP) (AA 52-100) antibodyBGLAP 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Osteocalcin (BGLAP) (AA 2-32) antibodyBGLAP 适用: 人 IHC, WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Osteocalcin (BGLAP) (AA 21-99) antibodyBGLAP 适用: 人 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Osteocalcin (BGLAP) (AA 21-99) antibodyBGLAP 适用: 人 IHC, WB 宿主: 小鼠 Monoclonal J10 unconjugated
anti-Osteocalcin (BGLAP) (AA 11-98) antibodyBGLAP 适用: 大鼠 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 1/1,000. Western blot: 1/100-1/500. Immunohistochemistry: 1/50-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.25 mg/mL
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缓冲液
- PBS with 0.09 % (W/V) Sodium Azide as preservative
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
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- Osteocalcin (BGLAP)
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别名
- Osteocalcin
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背景
- Prior to the formation of calcified bone, noncollagenous proteins form in the extracellular bone matrix. Gamma-carboxyglutamic acid residues are formed by vitamin K, vitamin-D regulated calcium binding proteins containing residues of Gla. These residues are essential for the binding of calcium and constitue 1-2 % of total bone protein. Osteocalcin itself binds strongly to apatite and calcium. Production of osteocalcin is expressed late in normal bone development and is characteristic of mature osteoblasts. Regular osteocalcin production has been shown to be linked to the p53 tumor suppressor gene. The p53 gene undergoes rearrangement in a high percentage of osteosarcomas, resulting in loss of its expression. The loss of p53 regulation inhibits further osteocalcin production. The absence of end-point differentiation in bone due to p53 rearrangements and lack of osteocalcin production may contribute to the maintenance of the tumorigenic phenotype in osteosarcomas.Synonyms: BGLAP, Bone Gla protein, Gamma-carboxyglutamic acid-containing protein
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分子量
- 10962 Da
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基因ID
- 632
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NCBI登录号
- NP_954642
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UniProt
- P02818
抗原
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