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ALPL 抗体 (N-Term)

This anti-ALPL antibody is a 兔 多克隆 antibody detecting ALPL in WB 和 EIA. Suitable for 人 和 小鼠.
产品编号 ABIN356989
发货至: 中国

Quick Overview for ALPL 抗体 (N-Term) (ABIN356989)

抗原

See all ALPL 抗体
ALPL (Alkaline Phosphatase, Liver/bone/kidney (ALPL))

适用

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人, 小鼠

宿主

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克隆类型

  • 91
  • 30
多克隆

标记

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This ALPL antibody is un-conjugated

应用范围

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Western Blotting (WB), Enzyme Immunoassay (EIA)
  • 抗原表位

    • 16
    • 13
    • 9
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    N-Term

    特异性

    This antibody detects Alkaline Phosphatase at N-term.

    纯化方法

    Protein A column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS

    免疫原

    This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human ALPL.

    亚型

    Ig Fraction
  • 应用备注

    ELISA 1: 1,000. Western blot 1: 50 - 1: 100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.25 mg/mL

    缓冲液

    PBS with 0.09 % (W/V) sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C/-20 °C

    储存方法

    Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
  • 抗原

    ALPL (Alkaline Phosphatase, Liver/bone/kidney (ALPL))

    别名

    Alkaline Phosphatase / ALPL

    背景

    There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The genes for the first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. This protein is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization, however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to a disorder known as hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms.Synonyms: AP-TNAP, Alkaline phosphatase, Alkaline phosphatase liver/bone/kidney isozyme, TNSALP, tissue-nonspecific isozyme

    分子量

    57323 Da

    基因ID

    249, 9606

    UniProt

    P05186
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