SNX6 抗体 (N-Term)
Quick Overview for SNX6 抗体 (N-Term) (ABIN356971)
抗原
See all SNX6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- This antibody detects SNX6 at N-term.
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纯化方法
- Protein A column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
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免疫原
- KLH conjugated synthetic peptide selected from the N-terminal region of human SNX6
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亚型
- Ig Fraction
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anti-Sorting Nexin 6 (SNX6) (AA 1-290) antibody
SNX6 适用: 人 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Sorting Nexin 6 (SNX6) antibodySNX6 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Sorting Nexin 6 (SNX6) (AA 1-290) antibodySNX6 适用: 人 ELISA, WB, IF 宿主: 小鼠 Monoclonal 3B11 unconjugated
anti-Sorting Nexin 6 (SNX6) (AA 211-310) antibodySNX6 适用: 小鼠, 大鼠 ELISA, WB, ICC, IF (cc), IF (p), IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Sorting Nexin 6 (SNX6) (AA 208-257) antibodySNX6 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 马, Bat, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA 1: 1,000. Western blot 1: 50 - 1: 100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.25 mg/mL
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缓冲液
- PBS with 0.09 % (W/V) sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
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- SNX6 (Sorting Nexin 6 (SNX6))
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别名
- Sorting Nexin-6 (SNX6)
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背景
- SNX6 interacts with members of the transforming growth factor-beta family of receptor serine-threonine kinases. These receptors belong to two classes: type II receptors that bind ligand, and type I receptors that are subsequently recruited to transduce the signal. Of the type II receptors, SNX6 was found to interact strongly with ActRIIB and more moderately with wild type and kinase-defective mutants of TbetaRII. Of the type I receptors, SNX6 was found to interact only with inactivated TbetaRI. SNXs 1-4 also interacted with the transforming growth factor-beta receptor family, showing different receptor preferences. Conversely, SNX6 behaved similarly to the other SNX proteins in its interactions with receptor tyrosine kinases. Strong heteromeric interactions were also seen among SNX1, -2, -4, and -6, suggesting the formation in vivo of oligomeric complexes. These findings are the first evidence for the association of the SNX family of molecules with receptor serine-threonine kinases.
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分子量
- 46649 Da
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基因ID
- 58533, 9606
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UniProt
- Q9UNH7
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途径
- EGFR Signaling Pathway
抗原
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