CBLC 抗体 (N-Term)
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北京 101111
Quick Overview for CBLC 抗体 (N-Term) (ABIN356778)
抗原
See all CBLC 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- This antibody is specific to Cbl (N-term).
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纯化方法
- Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
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免疫原
- This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human Cbl-c.
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亚型
- Ig Fraction
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anti-Cbl proto-oncogene C (CBLC) (AA 245-474) antibody
CBLC 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cbl proto-oncogene C (CBLC) (AA 245-474) antibodyCBLC 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cbl proto-oncogene C (CBLC) (AA 1-474) antibodyCBLC 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3F10 unconjugated
anti-Cbl proto-oncogene C (CBLC) (AA 244-474) antibodyCBLC 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 3B4 unconjugated
anti-Cbl proto-oncogene C (CBLC) (C-Term) antibodyCBLC 适用: 人 WB, ELISA, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Cbl proto-oncogene C (CBLC) (AA 1-474) antibodyCBLC 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Cbl proto-oncogene C (CBLC) (AA 244-474) antibodyCBLC 适用: 人 WB 宿主: 小鼠 Monoclonal 3D9 unconjugated
anti-Cbl proto-oncogene C (CBLC) (AA 424-453), (C-Term) antibodyCBLC 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB0696 unconjugated
anti-Cbl proto-oncogene C (CBLC) (AA 1-30), (N-Term) antibodyCBLC 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB0694 unconjugated
anti-Cbl proto-oncogene C (CBLC) antibodyCBLC 适用: 人 WB, IF, IC 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 1/1,000. Western blot: 1/100-1/500. Immunohistochemistry: 1/50-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.25 mg/mL
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缓冲液
- PBS containing 0.09 % (W/V) Sodium Azide as preservative.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
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- CBLC (Cbl proto-oncogene C (CBLC))
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别名
- CBLC / RNF57
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背景
- Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.Synonyms: CBL-3, CBL-C, CBL3, RING finger protein 57, SH3-binding protein CBL-C, Signal transduction protein CBL-C
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基因ID
- 23624, 9606
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UniProt
- Q9ULV8
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途径
- EGFR Signaling Pathway
抗原
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