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HDAC4 抗体 (C-Term)

Name: HDAC4 抗体 (C-Term)
SKU: ABIN356644
Availability: OutOfStock

HDAC4 适用: 人, 小鼠 WB, EIA 宿主: 兔 Polyclonal unconjugated

Image no. 1 for anti-Histone Deacetylase 4 (HDAC4) (C-Term) antibody (ABIN356644) (HDAC4 抗体 (C-Term))

1 image

产品编号 ABIN356644

发货至: 中国

Datasheet as PDF

抗原 See all HDAC4 抗体

HDAC4 (Histone Deacetylase 4 (HDAC4))
抗原表位
15

14

10

9

9

8

6

5

4

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
C-Term
适用
114

51

35

6

6

4

4

4

3

2

1

1

1

1
人, 小鼠
宿主
102

13

1
兔
Compatible Secondaries
克隆类型
103

13
多克隆
标记
72

8

7

6

3

3

2

2

2

2

2

2

1

1

1

1

1
This HDAC4 antibody is un-conjugated
应用范围
88

51

29

16

13

13

13

10

8

4

4

3

2

2

1

1

1
Western Blotting (WB), Enzyme Immunoassay (EIA)

特异性

This antibody is specific to HDAC4 (C-term).

纯化方法

Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

免疫原

This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human HDAC4.

亚型

Ig Fraction

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HDAC4 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Histone Deacetylase 4 (HDAC4) (AA 551-648) antibody
HDAC4 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 2B11 unconjugated

anti-Histone Deacetylase 4 (HDAC4) (AA 456-592) antibody
HDAC4 适用: 人 WB, ELISA, IHC, ICC, FACS 宿主: 小鼠 Monoclonal 5E4A5 unconjugated

anti-Histone Deacetylase 4 (HDAC4) antibody
HDAC4 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Histone Deacetylase 4 (HDAC4) (AA 451-650) antibody
HDAC4 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Histone Deacetylase 4 (HDAC4) (AA 1049-1077) antibody
HDAC4 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Histone Deacetylase 4 (HDAC4) (pSer632) antibody
HDAC4 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Histone Deacetylase 4 (HDAC4) (AA 530-630) antibody
HDAC4 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated

anti-Histone Deacetylase 4 (HDAC4) (Ser632) antibody
HDAC4 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Histone Deacetylase 4 (HDAC4) (N-Term) antibody
HDAC4 适用: 人 WB, IP 宿主: 小鼠 Monoclonal unconjugated

应用备注

ELISA: 1/1,000. Western Blot: 1-100-1/500.

限制

仅限研究用
状态

Liquid

浓度

0.25 mg/mL

缓冲液

PBS containing 0.09 % (W/V) Sodium Azide as preservative.

储存液

Sodium azide

注意事项

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C/-20 °C

储存方法

Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
抗原

HDAC4 (Histone Deacetylase 4 (HDAC4))

别名

HDAC4 (HDAC4 产品)

别名

CG1770 antibody, DHDAC4 antibody, Dmel\\CG1770 antibody, GC1770 antibody, HDAC antibody, HDAC4a antibody, dHDAC4 antibody, dmHDA405 antibody, hdac4 antibody, dana_GLEANR_19966 antibody, DanaGF18710 antibody, GF18710 antibody, HDAC4 antibody, AHO3 antibody, BDMR antibody, HA6116 antibody, HD4 antibody, HDAC-4 antibody, HDAC-A antibody, HDACA antibody, 4932408F19Rik antibody, AI047285 antibody, wu:fa96d08 antibody, wu:fc56f08 antibody, zgc:152701 antibody, histone deacetylase 4 antibody, hypothetical protein antibody, Histone deacetylase 4 antibody, GF18710 gene product from transcript GF18710-RC antibody, PTRG_03699 antibody, PGTG_15512 antibody, HDAC4 antibody, Dana\GF18710 antibody, Hdac4 antibody, hdac4 antibody

背景

DNA is wrapped around histone proteins to form nucleosomes and chromatin fiber, a higher-order structure. Chromatin can become alternatively revealed to or concealed from transcription factors. Acetylation of lysine residues induces conformational changes in core histones by destabilizing nucleosomes and allowing transcription factors access to recognition elements in DNA. Deacetylation of histones by histone deacetylases (HDACs) reseals the chromosomal package, leading to a repression of transcription. HDAC4 does not bind DNA directly, but rather through MEF2C and MEF2D. Binding of the N terminus of HDAC4 to MEF2C represses MEF2C transcription activity. The catalytic domain of HDAC4 interacts with HDAC3 via the transcriptional corepressor NCOR2. Experimental conditions leading to the suppression of HDAC4 binding to NCOR2 and to HDAC3 result in loss of enzymatic activity associated with HDAC4, indicating regulation of transcription by bridging the enzymatically active NCOR2-HDAC3 complex and select transcription factors. HDAC4 and MITR contain calmodulin-binding domains that overlap with their MEF2 binding domains. Binding of calmodulin to HDAC4 leads to its dissociation from MEF2, relieving MEF2 from the transcriptional repression by HDAC4. Together, HDAC4, MITR, and CABIN1 constitute a family of calcium-sensitive transcriptional repressors of MEF2. In murine studies, HDAC4, which is expressed in prehypertrophic chondrocytes, interacts with and inhibits the activity of Runx2 in mice, a transcription factor necessary for chondrocyte hypertrophy, establishing HDAC4 as a central regulator of chondrocyte hypertrophy and skeletogenesis.Synonyms: HD4, Histone deacetylase 4, KIAA0288

基因ID

9759, 9606

UniProt

P56524

途径

Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process