BST1 抗体
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北京 101111
Quick Overview for BST1 抗体 (ABIN356330)
抗原
See all BST1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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产品特性
- Synonyms: Blood Group Tn Antigen
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纯化方法
- PBS, pH 7.4 containing 0.05% Sodium Azide as preservative.
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免疫原
- Asialo ovine submaxillary mucin (AOSM). Remarks: Molecular weight of antigen: Several HM weight glycoproteins. Epitope: alpha GalNacOSer/Thr.
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亚型
- IgM
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应用备注
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Suitable for Immunohistochemistry and Immunocytochemistry (Frozen or Formalin-FixedParaffin-Embedded (FFPE) tissue sections and cell smears)For IHC dilute concentared antibody at 1/50-1/100, use streptavidinapprox. biotin system orpolymer system, incubate 30 minutes at room temperature. Immunofluorescence. Recommended Positive Control: Human gastrointestinal tumor.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 0.2 mg/mL
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储存条件
- 4 °C/-20 °C
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储存方法
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Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: One year from despatch. -
有效期
- 12 months
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- BST1 (Bone Marrow Stromal Cell Antigen 1 (BST1))
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别名
- CD175
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背景
- Aberrant glycosylation is a hallmark of cancer cells. The blood group precursors T (Thomsen-Friedenreich) and Tn epitopes are shielded in healthy and benign-diseased tissues but uncovered in approx. 90 % of carcinomas. T and Tn glycoproteins are specific, autoimmunogenic pancarcinoma antigens. These antigens may also be found in neoplastic blood cells Fundamental chemical and physical aspects of these glycoproteins of primary carcinomas are discussed first. Tn and T epitopes are cell and tissue adhesion molecules, essential in invasion by and metastasis of carcinoma which includes adherent and proliferative phases. Immunohistochemical studies of the extent of Tn antigen expression in primary breast carcinoma demonstrate it highly significant correlation with clinicopathological tumor stages, and hence its value as a reliable prognosticator.Synonyms: Blood Group Tn Antigen
抗原
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