VAMP7 抗体
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- 抗原 See all VAMP7 抗体
- VAMP7 (Vesicle-Associated Membrane Protein 7 (VAMP7))
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适用
- 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This VAMP7 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 特异性
- Specific for VAMP7.
- 交叉反应
- 人, Marmoset, 小鼠, 大鼠
- 交叉反应 (详细)
- Other species not yet tested.
- 纯化方法
- IgG
- 免疫原
- A synthetic peptide from rat VAMP7 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in mouse and human.
- 亚型
- IgG
- Top Product
- Discover our top product VAMP7 Primary Antibody
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- 应用备注
- IHC, WB. A working concentration of 10-50 μg,ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Reconstitute in 500 μL of sterile water. Centrifuge to remove any insoluble material.
- 注意事项
- Avoid freeze and thaw cycles.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
- 有效期
- 12 months
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- 抗原
- VAMP7 (Vesicle-Associated Membrane Protein 7 (VAMP7))
- 别名
- VAMP 7 (VAMP7 产品)
- 背景
- FUNCTION: Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation. SUBUNIT: Component of the SNARE complex composed of STX4, SNAP23 and VAMP7 that binds SYT7 during lysosomal exocytosis. Component of the SNARE complex composed of STX7, STX8, VAMP7 and VTI1B that is required for heterotypic fusion of late endosomes with lysosomes in liver cells. SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane, Single-pass type IV membrane protein. Golgi apparatus, trans-Golgi network membrane, Single-pass type IV membrane protein. Late endosome membrane, Single-pass type IV membrane protein. Lysosome membrane, Single-pass type IV membrane protein. Endoplasmic reticulum membrane, Single-pass type IV membrane protein. Cytoplasmic vesicle, phagosome membrane, Single-pass type IV membrane protein. TISSUE SPECIFICITY: Detected in all tissues tested.,Vesicle Transport,Vesicle-associated membrane protein 7, SYBL1, Synaptobrevin-like protein 1, Tetanus-insensitive VAMP, Ti-VAMP, SYBL1
- UniProt
- Q9JHW5
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