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VAMP7 抗体

This anti-VAMP7 antibody is a 兔 多克隆 antibody detecting VAMP7 in WB 和 IHC. Suitable for 大鼠.
产品编号 ABIN351365
发货至: 中国

Quick Overview for VAMP7 抗体 (ABIN351365)

抗原

See all VAMP7 抗体
VAMP7 (Vesicle-Associated Membrane Protein 7 (VAMP7))

适用

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大鼠

宿主

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克隆类型

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多克隆

标记

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This VAMP7 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC)
  • 原理

    Rabbit antibody to VAMP7

    特异性

    Specific for VAMP7.

    交叉反应

    人, Marmoset, 小鼠, 大鼠

    交叉反应 (详细)

    Other species not yet tested.

    纯化方法

    IgG

    免疫原

    A synthetic peptide from rat VAMP7 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in mouse and human.

    亚型

    IgG
  • 应用备注

    IHC WB. A working concentration of 10-50,micro,g,ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.

    限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Reconstitute in 500 µl of sterile water. Centrifuge to remove any insoluble material.

    注意事项

    Avoid freeze and thaw cycles.

    储存条件

    4 °C,-20 °C

    储存方法

    Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

    有效期

    12 months
  • 抗原

    VAMP7 (Vesicle-Associated Membrane Protein 7 (VAMP7))

    别名

    VAMP7

    背景

    FUNCTION: Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation. SUBUNIT: Component of the SNARE complex composed of STX4 SNAP23 and VAMP7 that binds SYT7 during lysosomal exocytosis. Component of the SNARE complex composed of STX7 STX8 VAMP7 and VTI1B that is required for heterotypic fusion of late endosomes with lysosomes in liver cells. SUBCELLULAR LOCATION: Cytoplasmic vesicle secretory vesicle membrane, Single-pass type IV membrane protein. Golgi apparatus trans-Golgi network membrane, Single-pass type IV membrane protein. Late endosome membrane, Single-pass type IV membrane protein. Lysosome membrane, Single-pass type IV membrane protein. Endoplasmic reticulum membrane, Single-pass type IV membrane protein. Cytoplasmic vesicle phagosome membrane, Single-pass type IV membrane protein. TISSUE SPECIFICITY: Detected in all tissues tested.

    UniProt

    Q9JHW5
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