SHANK3 抗体
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北京 101111
Quick Overview for SHANK3 抗体 (ABIN350832)
抗原
See all SHANK3 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- Rabbit antibody to SHANK3
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特异性
- Specific for SHANK3.
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交叉反应
- 人, 小鼠, 大鼠
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交叉反应 (详细)
- Other species not yet tested.
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纯化方法
- IgG
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免疫原
- A synthetic peptide from human SHANK3 conjugated to blue carrier protein was used as the antigen.
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亚型
- IgG
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应用备注
- IHC WB. A concentration of 10-50 μg,ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
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注意事项
- Avoid freeze and thaw cycles.
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储存条件
- 4 °C,-20 °C
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储存方法
- Maintain the lyophilised/reconstituted antibodies frozen at -20C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
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有效期
- 12 months
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- SHANK3 (SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3))
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别名
- SHANK3
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背景
- Function: Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer respectively and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction. Subcellular location: Cytoplasm. Cell junction ‰ synapse. Cell junction ‰ synapse ‰ postsynaptic cell membrane ‰ postsynaptic density. Note: Postsynaptic density of neuronal cells. Extends into the region subjacent to the PSD. Tissue specificity: Widely expressed in brain.
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UniProt
- Q9BYB0
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途径
- Synaptic Membrane, Tube Formation, Regulation of long-term Neuronal Synaptic Plasticity
抗原
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