CHMP3
(Charged Multivesicular Body Protein 3 (CHMP3))
抗原表位
N-Term
适用
人
宿主
绵羊
克隆类型
多克隆
标记
This CHMP3 antibody is un-conjugated
应用范围
Western Blotting (WB), Immunohistochemistry (IHC)
原理
Sheep antibody to CHMP3
特异性
Specific for CHMP3.
交叉反应
人, 小鼠, 大鼠
交叉反应 (详细)
Other species not yet tested.
纯化方法
IgG
免疫原
A synthetic peptide from the n-terminal of human CHMP3 conjugated to an immunogenic carrier protein was used as the antigen. The antigen is homologous in rat and mouse.
IHC WB. A concentration of 10-50,micro,g,ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.
限制
仅限研究用
状态
Lyophilized
溶解方式
Reconstitute in 500 µl of sterile water. Centrifuge to remove any insoluble material.
注意事项
Avoid freeze and thaw cycles.
储存条件
4 °C,-20 °C
储存方法
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
有效期
12 months
抗原
CHMP3
(Charged Multivesicular Body Protein 3 (CHMP3))
FUNCTION: Component of the ESCRT-III complex which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-III complex is probably involved in the concentration of MVB cargo. Required for sorting/trafficking of EGF receptor. In case of infection the HIV-1 virus takes advantage of the ESCRT-III complex for budding and exocytic cargos of viral proteins. SUBCELLULAR LOCATION: Cytoplasm cytosol. Membrane, Lipid-anchor. TISSUE SPECIFICITY: Widely expressed. Expressed in heart brain placenta lung liver skeletal muscle kidney and pancreas.