THRB 抗体 (N-Term)
(3 references)
Quick Overview for THRB 抗体 (N-Term) (ABIN349600)
抗原
See all THRB 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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Supplier Product No.
- 600-401-a96
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Supplier
- Rockland
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原理
- Thyroid Hormone Receptor beta 1 Antibody
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交叉反应 （详细）
- This antibody reacts with human THRB protein.
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产品特性
- Synonyms: Rabbit anti-THRB antibody, rabbit anti-Thyroid hormone receptor beta 1 antibody, Anti-THRB1 antibody, c-erbA-beta, THR1 antibody, c-erbA-2, Nuclear receptor subfamily 1 group A member 2, ERBA2, NR1A2
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纯化方法
- This product was affinity purified from monospecific antiserum by immunoaffinity chromatography.
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过滤
- Sterile filtered
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免疫原
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Immunogen: Anti-TR ß1 antibody is affinity purified from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a region near the N-terminal of human THRB isoform 1 protein.
Immunogen Type: Conjugated Peptide
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亚型
- IgG
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anti-Thyroid Hormone Receptor, beta (THRB) (AA 1-169) antibody
THRB 适用: 人 WB, IHC, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Thyroid Hormone Receptor, beta (THRB) (AA 1-461) antibodyTHRB 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Thyroid Hormone Receptor, beta (THRB) (AA 239-457) antibodyTHRB 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Thyroid Hormone Receptor, beta (THRB) (AA 37-86) antibodyTHRB 适用: 人, 大鼠, 马, 犬, 豚鼠, 兔, 猴, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Thyroid Hormone Receptor, beta (THRB) (AA 1-250) antibodyTHRB 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Thyroid Hormone Receptor, beta (THRB) (N-Term) antibodyTHRB 适用: 人 WB 宿主: 小鼠 Monoclonal 2386 unconjugated
anti-Thyroid Hormone Receptor, beta (THRB) (N-Term) antibodyTHRB 适用: 人, 小鼠, 大鼠, 马, 犬, 兔, 绵羊 WB, ChIP 宿主: 兔 Polyclonal unconjugated
anti-Thyroid Hormone Receptor, beta (THRB) (N-Term) antibodyTHRB 适用: 人, 小鼠, 大鼠, 马, 豚鼠, Cow WB, ChIP 宿主: 兔 Polyclonal unconjugated
anti-Thyroid Hormone Receptor, beta (THRB) (AA 391-440) antibodyTHRB 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Thyroid Hormone Receptor, beta (THRB) (AA 23-55) antibodyTHRB 适用: 人 WB 宿主: 兔 Polyclonal RB54428 unconjugated
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应用备注
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Application Note: This affinity purified antibody has been tested for use in ELISA, IF, and western blotting.
Western Blot Dilution: 1:500 - 1:2,000
Immunoprecipitation Dilution: 1:100
ELISA Dilution: 1:20,000 - 1:200,000
IF Microscopy Dilution: 1:1000
Other: User Optimized
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1.0 mg/mL
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缓冲液
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Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Stabilizer: None
Preservative: 0.01 % (w/v) Sodium Azide -
储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store Anti-TR beta1 antibody at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
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有效期
- 12 months
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: "Oncogenic Actions of the Nuclear Receptor Corepressor (NCOR1) in a Mouse Model of Thyroid Cancer." in: PLoS ONE, Vol. 8, Issue 6, pp. e67954, (2017) (PubMed).
: "Role of TSH in the spontaneous development of asymmetrical thyroid carcinoma in mice with a targeted mutation in a single allele of the thyroid hormone-β receptor." in: Endocrinology, Vol. 153, Issue 10, pp. 5090-100, (2012) (PubMed).
: "Nuclear factor (NF)-kappaB-dependent thyroid hormone receptor beta1 expression controls dendritic cell function via Akt signaling." in: The Journal of biological chemistry, Vol. 285, Issue 13, pp. 9569-82, (2010) (PubMed).
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: "Oncogenic Actions of the Nuclear Receptor Corepressor (NCOR1) in a Mouse Model of Thyroid Cancer." in: PLoS ONE, Vol. 8, Issue 6, pp. e67954, (2017) (PubMed).
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- THRB (Thyroid Hormone Receptor, beta (THRB))
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别名
- THRB
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背景
- Background: Anti-Thyroid Hormone Receptor ß1 (TRB1) antibody is designed, produced, and validated as part of a collaboration with the National Cancer Institute (NCI) and is suitable for Cancer, Immunology and Nuclear Signaling research. The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Defects in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). This TRB1 antibody is ideal for Immunology, Thyroid and Signal Transduction research.
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基因ID
- 7068, 40806162
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UniProt
- P10828
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途径
- Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Sensory Perception of Sound
抗原
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