DPYSL3 抗体 (C-Term)
Quick Overview for DPYSL3 抗体 (C-Term) (ABIN347041)
抗原
See all DPYSL3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- Reacts with 65 kDa CRMP-4 from human rat and mouse
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交叉反应 (详细)
- Do not react with CRMP-1, CRMP-2, CRMP-3 or CRMP-5.
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纯化方法
- Antiserum
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免疫原
- A 15 residue synthetic peptide derived from C-terminal domain of human collapsing-response mediator
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亚型
- IgG
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应用备注
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Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
-IHC : 1/500 - WB :1/2 000 -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Must be reconstituted in distilled water.
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储存条件
- 4 °C/-20 °C
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储存方法
- Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.
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有效期
- 24 months
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A rare motor neuron deleterious missense mutation in the DPYSL3 (CRMP4) gene is associated with ALS." in: Human mutation, Vol. 34, Issue 7, pp. 953-60, (2013) (PubMed).
: "Differential expression of CRMP1, CRMP2A, CRMP2B, and CRMP5 in axons or dendrites of distinct neurons in the mouse brain." in: The Journal of comparative neurology, Vol. 486, Issue 1, pp. 1-17, (2005) (PubMed).
: "Isolation and expression pattern of human Unc-33-like phosphoprotein 6/collapsin response mediator protein 5 (Ulip6/CRMP5): coexistence with Ulip2/CRMP2 in Sema3a- sensitive oligodendrocytes." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 21, Issue 18, pp. 7203-14, (2001) (PubMed).
: "Ulip/CRMP proteins are recognized by autoantibodies in paraneoplastic neurological syndromes." in: The European journal of neuroscience, Vol. 11, Issue 12, pp. 4226-32, (2000) (PubMed).
: "Analysis of transglutaminase-catalyzed isopeptide bonds in paired helical filaments and neurofibrillary tangles from Alzheimer's disease." in: Methods in enzymology, Vol. 309, pp. 172-86, (1999) (PubMed).
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A rare motor neuron deleterious missense mutation in the DPYSL3 (CRMP4) gene is associated with ALS." in: Human mutation, Vol. 34, Issue 7, pp. 953-60, (2013) (PubMed).
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- DPYSL3 (Dihydropyrimidinase-Like 3 (DPYSL3))
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别名
- Collapsin Response Mediator Protein 4 (CRMP-4)
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背景
- Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration
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UniProt
- Q14195
抗原
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