CD56 抗体
(7 references)-
- 抗原 See all CD56 (NCAM1) 抗体
- CD56 (NCAM1) (Neural Cell Adhesion Molecule 1 (NCAM1))
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适用
- 人, 斑马鱼
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This CD56 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)
- 特异性
- Human.
- 纯化方法
- Purified
- 免疫原
- 123C3 is a mouse monoclonal IgG1 antibody derived by fusion of mouse myeloma cells with spleen cells from a mouse immunized with the a membrane preparation of a small cell lung carcinoma specimen.
- 克隆位点
- 123C3
- 亚型
- IgG1
- Top Product
- Discover our top product NCAM1 Primary Antibody
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anti-Neural Cell Adhesion Molecule 1 (NCAM1) (AA 759-858) antibody
NCAM1 适用: 人 WB, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Neural Cell Adhesion Molecule 1 (NCAM1) antibodyNCAM1 适用: 人 FACS, WB, IHC, ELISA 宿主: 小鼠 Monoclonal 5B1G11 unconjugated
anti-Neural Cell Adhesion Molecule 1 (NCAM1) antibodyNCAM1 适用: 人, 大鼠 FACS, WB, IHC, IF, StM 宿主: 小鼠 Monoclonal NCAM1-795 unconjugated
anti-Neural Cell Adhesion Molecule 1 (NCAM1) (Internal Region) antibodyVerified NCAM1 适用: 人 FACS, WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Neural Cell Adhesion Molecule 1 (NCAM1) antibody (PerCP)NCAM1 适用: 人, Non-Human Primate FACS 宿主: 小鼠 Monoclonal MEM-188 PerCP
anti-Neural Cell Adhesion Molecule 1 (NCAM1) (AA 568-708) antibodyNCAM1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1F6F10 unconjugated
anti-Neural Cell Adhesion Molecule 1 (NCAM1) (AA 701-800) antibodyNCAM1 适用: 人, 大鼠, 小鸡 FACS, WB, ELISA, IHC (p), IHC (fro), IF (p), IF (cc) 宿主: 兔 Polyclonal unconjugated
anti-Neural Cell Adhesion Molecule 1 (NCAM1) (AA 340-608) antibodyNCAM1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Neural Cell Adhesion Molecule 1 (NCAM1) (AA 796-830), (C-Term) antibodyNCAM1 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB51135 unconjugated
anti-Neural Cell Adhesion Molecule 1 (NCAM1) antibodyNCAM1 适用: 人, 小鼠 FACS, IHC, ICC 宿主: 小鼠 Monoclonal RNL-1 unconjugated
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- 应用备注
- 123C3 was defined as a cluster I antibody during the First International Workshop on Small Cell Lung Cancer (SCLC) Antibodies. 123C3 recognizes an epitope in the NCAM exons 11-13 which is dependent on an intact conformation of the first fibronectin type-III homologous domain encoded by these exons. 123C3 stains NCAM which is present in small cell lung cancer and lung carcinoids. It also reacts with a number of non-small cell lung carcinomas and neuroendocrine and neuronal derived tissues. In addition, 123C3 is internalized after binding to its antigen on SCLC cell lines, making it an excellent reagent for tumor imaging in xenograft models. 123C3 is suitable for immunoblotting, immunocytochemistry and immunohistochemistry on frozen and paraffin-embedded tissues. Optimal antibody dilution should be determined by titration, recommended range is 1:100 - 1:200 for immunohistochemistry with avidin-biotinylated horseradish peroxidase complex (ABC) as detection reagent, and 1:100 - 1:1000 for immunoblotting applications.
- 限制
- 仅限研究用
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- 储存条件
- 4 °C
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: "Prognostic factors in resected non-small cell lung cancer: an immunohistochemical study of 39 cases." in: Lung cancer (Amsterdam, Netherlands), Vol. 16, Issue 1, pp. 35-45, (1997) (PubMed).
: "Radioimmunotherapy of small-cell lung cancer xenografts using 131I-labelled anti-NCAM monoclonal antibody 123C3." in: Cancer immunology, immunotherapy : CII, Vol. 41, Issue 3, pp. 169-74, (1995) (PubMed).
: "Hot spots of antigenicity in the neural cell adhesion molecule NCAM." in: International journal of cancer. Supplement = Journal international du cancer. Supplement, Vol. 8, pp. 38-42, (1994) (PubMed).
: "Neural cell adhesion molecule expression, neuroendocrine differentiation and prognosis in lung carcinoma." in: European journal of cancer (Oxford, England : 1990), Vol. 27, Issue 4, pp. 431-5, (1991) (PubMed).
: "Expression of neural cell adhesion molecule-related sialoglycoprotein in small cell lung cancer and neuroblastoma cell lines H69 and CHP-212." in: Cancer research, Vol. 50, Issue 4, pp. 1102-6, (1990) (PubMed).
: "Monoclonal antibody 123C3, identifying small cell carcinoma phenotype in lung tumours, recognizes mainly, but not exclusively, endocrine and neuron-supporting normal tissues." in: International journal of cancer. Supplement = Journal international du cancer. Supplement, Vol. 2, pp. 34-40, (1988) (PubMed).
: "Monoclonal antibody 123C3 in lung tumour classification. Immunohistology of 358 resected lung tumours." in: Molecular and cellular probes, Vol. 2, Issue 1, pp. 31-7, (1988) (PubMed).
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: "Prognostic factors in resected non-small cell lung cancer: an immunohistochemical study of 39 cases." in: Lung cancer (Amsterdam, Netherlands), Vol. 16, Issue 1, pp. 35-45, (1997) (PubMed).
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- 抗原
- CD56 (NCAM1) (Neural Cell Adhesion Molecule 1 (NCAM1))
- 别名
- NCAM / CD56 (NCAM1 产品)
- 背景
- NCAM, as a member of the immunoglobulin superfamily of adhesion molecules is characterized by several immunoglobulin (Ig)-like domains. The extracellular part of NCAM consists of five of these Ig domains and two fibronectin type III homology regions. NCAM is encoded by a single copy gene composed of 26 exons. However, at least 20-30 distinct isoforms can be generated by alternative splicing and by posttranslational modifications, such as sialylation. During sialylation, polysialic acid (PSA) carbohydrates are attached to the extracellular part of NCAM. Through its extracellular region, NCAM mediates homophilic interactions. In addition, NCAM can also undergo heterophilic interactions by binding extracellular matrix components, such as laminin, or other cell adhesion molecules, such as integrins.
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