Integrin Beta1D 抗体
LOC395211
适用: 人, 小鼠, 犬
IHC, WB, ICC, IHC (fro)
宿主: 小鼠
Monoclonal
2B1
unconjugated
(1 reference)-
- 抗原 See all Integrin Beta1D (LOC395211) products
- Integrin Beta1D (LOC395211)
- 适用
- 人, 小鼠, 犬
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This Integrin Beta1D antibody is un-conjugated
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应用范围
- Immunohistochemistry (IHC), Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 特异性
- Human, mouse and dog. A broad species reactivity is expected because of the conserved nature of the epitope.
- 纯化方法
- Purified
- 免疫原
- 2B1 is a mouse monoclonal IgG1, kappa antibody derived by fusion of SP2/0 mouse myeloma cells with spleen cells from a mouse immunized with a synthetic peptide corresponding to the C-terminal 24 amino acids of integrin beta1D including an appending N-terminal cysteine (CQENPIYKS- PINNFKNPNYGRKAGL) coupled to keyhole limpet hemocyanin.
- 克隆位点
- 2B1
- 亚型
- IgG1
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- 应用备注
- 2B1 recognizes specifically the cytoplasmic domain of integrin subunit beta1D present in cardiac and skeletal muscle. 2B1 is suitable for immunoblotting, immunocytochemistry and immunohistochemistry on frozen tissues. Optimal antibody dilution should be determined by titration, recommended range is 1:25 - 1:200 for immunohistochemistry with avidin-biotinylated horseradish peroxidase complex (ABC) as detection reagent, and 1:100 - 1:1000 for immunoblotting applications.
- 限制
- 仅限研究用
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- 储存条件
- 4 °C
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: "Spatial and temporal expression of the beta1D integrin during mouse development." in: Developmental dynamics : an official publication of the American Association of Anatomists, Vol. 210, Issue 4, pp. 472-86, (1998) (PubMed).
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: "Spatial and temporal expression of the beta1D integrin during mouse development." in: Developmental dynamics : an official publication of the American Association of Anatomists, Vol. 210, Issue 4, pp. 472-86, (1998) (PubMed).
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- 抗原
- Integrin Beta1D (LOC395211)
- 别名
- Integrin beta 1D (LOC395211 产品)
- 背景
- Integrins are a family of heterodimeric membrane glycoproteins consisting of non-covalently associated alpha and beta subunits. More than 18 alpha and 8 beta subunits with numerous splice variant isoforms have been identified in mammals. In general, integrins function as receptors for extracellular matrix proteins. Certain integrins can also bind to soluble ligands or to counter-receptors on adjacent cells, such as the intracellular adhesion molecules (ICAMs), resulting in aggregation of cells. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. There are two major forms of integrin beta1: beta1A and beta1D, which differ in 13 amino acids. Their distribution pattern in adult tissues is mutually exclusive. beta1A is present in all tissues, except cardiac and skeletal muscle, which instead express the beta1D variant.
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