GFAP 抗体
Quick Overview for GFAP 抗体 (ABIN335275)
抗原
See all GFAP 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- Human, mouse and rat.
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纯化方法
- Antiserum
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免疫原
- K39 is a rabbit polyclonal antiserum derived by immunization of a rabbit with a glial fibrillary acidic protein preparation from human spinal cord.
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应用备注
- K39 reacts exclusively with glial fibrillary acidic protein which is present in astrocytes in the central nervous system and Schwann cells. K39 is suitable for immunoblotting and immunohistochemistry on frozen and paraffin-embedded tissues. Optimal antibody dilution should be determined by titration, recommended range is 1:100 - 1:200 for immunohistochemistry with avidin-biotinylated horseradish peroxidase complex (ABC) as detection reagent, and 1:100 - 1:1000 for immunoblotting applications.
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限制
- 仅限研究用
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状态
- Liquid
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储存条件
- 4 °C
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: "Co-expression of glial fibrillary acidic protein- and vimentin-type intermediate filaments in human astrocytomas." in: Acta neuropathologica, Vol. 70, Issue 3-4, pp. 333-9, (1986) (PubMed).
: "Antibodies to intermediate filament proteins in the immunohistochemical identification of human tumours: an overview." in: The Histochemical journal, Vol. 15, Issue 7, pp. 691-713, (1983) (PubMed).
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: "Co-expression of glial fibrillary acidic protein- and vimentin-type intermediate filaments in human astrocytomas." in: Acta neuropathologica, Vol. 70, Issue 3-4, pp. 333-9, (1986) (PubMed).
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- GFAP (Glial Fibrillary Acidic Protein (GFAP))
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别名
- Glial fibrillary acidic protein / GFAP
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背景
- GFAP (55 kD) is selectively located in astrocytes and represents the major constituent of astrocytic intermediate filaments. GFAP expression levels are highly variable during development of the central nervous system. In adults, GFAP levels increase as a result of the proliferation of astrocytes that occurs in a response to a variety of physical, chemical and etiological insults, including Alzheimer€™s disease, epilepsy and multiple sclerosis. In the peripheral nervous system GFAP is expressed by Schwann cells. Upon differentiation, myelin forming Schwann cells down-regulate GFAP, whereas in non-myelin forming Schwann cells GFAP persists into adulthood.
抗原
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