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Integrin Alpha2b 抗体

This anti-Integrin Alpha2b antibody is a 大鼠 单克隆 antibody detecting Integrin Alpha2b in FACS, IP 和 IHC (fro). Suitable for 小鼠. This Primary Antibody has been cited in 6+ publications.
产品编号 ABIN320116
发货至: 中国

Quick Overview for Integrin Alpha2b 抗体 (ABIN320116)

抗原

See all Integrin Alpha2b (CD41) 抗体
Integrin Alpha2b (CD41)

适用

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小鼠

宿主

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大鼠

克隆类型

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单克隆

标记

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This Integrin Alpha2b antibody is un-conjugated

应用范围

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Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))

克隆位点

MWReg30
  • 特异性

    This antibody recognizes the integrin alpha IIb subunit CD41. Clone MWReg30 has been reported to inhibit PMA induced aggregation in vitro and to induce hypothermia in vivo (Nieswandt et al., 1999). SM2035A is recommended for use in functional studies.

    纯化方法

    Affinity Chromatography on Protein G.

    亚型

    IgG1
  • 应用备注

    Flow Cytometry (1/50-1/100): Use 10 μL to label 10^6 cells in 100 μL. Immunohistology on Frozen Sections. Immunoprecipitation.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 浓度

    1.0 mg/mL

    缓冲液

    PBS, containing 0.09 % Sodium Azide as preservative.

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    -20 °C
  • Koski, Bramante, Kipar, Oksanen, Juhila, Vassilev, Joensuu, Kanerva, Hemminki: "Biodistribution Analysis of Oncolytic Adenoviruses in Patient Autopsy Samples Reveals Vascular Transduction of Noninjected Tumors and Tissues." in: Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 23, Issue 10, pp. 1641-52, (2016) (PubMed).

    Pennings, Siljee, Imholz, Kuc, de Vries, Schielen, Rodenburg: "Comparison of different blood collection, sample matrix, and immunoassay methods in a prenatal screening setting." in: Disease markers, Vol. 2014, pp. 509821, (2015) (PubMed).

    Teeling, Carare, Glennie, Perry: "Intracerebral immune complex formation induces inflammation in the brain that depends on Fc receptor interaction." in: Acta neuropathologica, Vol. 124, Issue 4, pp. 479-90, (2012) (PubMed).

    Haglund, Tillgren, Addis, Wenglén, Recklies, Heinegård: "Identification and characterization of the integrin alpha2beta1 binding motif in chondroadherin mediating cell attachment." in: The Journal of biological chemistry, Vol. 286, Issue 5, pp. 3925-34, (2011) (PubMed).

    Sullivan, Wang, Tawfik, Luyendyk: "Protective and damaging effects of platelets in acute cholestatic liver injury revealed by depletion and inhibition strategies." in: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 115, Issue 1, pp. 286-94, (2010) (PubMed).

    Leung, Greene, Ni, Raymond, Lehnert, Langley, Krissansen: "Cloning of the mucosal addressin MAdCAM-1 from human brain: identification of novel alternatively spliced transcripts." in: Immunology and cell biology, Vol. 74, Issue 6, pp. 490-6, (1997) (PubMed).

  • 抗原

    Integrin Alpha2b (CD41)

    别名

    CD41 / ITGA2B

    背景

    CD41, a ~125 kDa single pass type 1 transmembrane glycoprotein, is expressed on platelets, megakaryocytes, mast cells and hematopoietic progenitors and forms a heterodimer with CD61. CD41/CD61 is important for platelet adhesion and aggregation.Synonyms: GP2B, GPalpha IIb, ITGAB, Integrin alpha-IIb, Platelet membrane glycoprotein IIb

    基因ID

    16399

    NCBI登录号

    NP_034705

    UniProt

    Q9QUM0

    途径

    Integrin Complex
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