SNCA 抗体 (pSer129)
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Quick Overview for SNCA 抗体 (pSer129) (ABIN318946)
抗原
See all SNCA 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer129
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特异性
- This antibody specifically recognises rat alpha synuclein when phosphorylated at Ser129.
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纯化方法
- Purified
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免疫原
- Synthetic phosphopeptide corresponding to amino acid sequence surrounding phosphorylated serine 129 of Alpha Synuclein.
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亚型
- IgG
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anti-Synuclein, alpha (SNCA) (pSer129) antibody
SNCA 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (PerCP)SNCA 适用: 人 WB, ELISA, IHC, ICC 宿主: 兔 Monoclonal J18 PerCP
anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (PE)SNCA 适用: 人 WB, ELISA, IHC, ICC 宿主: 兔 Monoclonal J18 PE
anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (Atto 488)SNCA 适用: 人 WB, ELISA, IHC, ICC 宿主: 兔 Monoclonal J18 Atto 488
anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (Atto 390)SNCA 适用: 人 WB, ELISA, IHC, ICC 宿主: 兔 Monoclonal J18 Atto 390
anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (Atto 594)SNCA 适用: 人 WB, ELISA, IHC, ICC 宿主: 兔 Monoclonal J18 Atto 594
anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (Biotin)SNCA 适用: 人 WB, ELISA, IHC, ICC 宿主: 兔 Monoclonal J18 Biotin
anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (FITC)SNCA 适用: 人 WB, ELISA, IHC, ICC 宿主: 兔 Monoclonal J18 FITC
anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (APC)SNCA 适用: 人 WB, ELISA, IHC, ICC 宿主: 兔 Monoclonal J18 APC
anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (HRP)SNCA 适用: 人 WB, ELISA, IHC, ICC 宿主: 兔 Monoclonal J18 HRP
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应用备注
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Western Blot: 1: 1000, detects a band of approximately 15 kDa in rat cortex lysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 10 mM Hepes pH 7.5, 150 mM NaCl containing 0.09 % Sodium Azide (NaN3), 50 % Glycerol 0.01 % Bovine Serum Albumin
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储存液
- Sodium azide
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注意事项
- This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- SNCA (Synuclein, alpha (SNCA))
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别名
- alpha-Synuclein / SNCA
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背景
- Alpha synuclein is a 140 amino acid, 15 kDa protein seen predominantly in the neocortex, hippocampus, substantia nigra, thalamus and cerebellum. Its normal cellular function has not been definitively determined, but it is thought to be involved in the regulation of neuronal plasticity, dopamine neurotransmission and other membrane-associated processes at the presynaptic terminal. Alpha synuclein is normally a soluble, unfolded protein, but it can aggregate at high concentrations to form insoluble fibrils which, in association with other proteins such as ubiquitin, neurofilament protein and alpha B crystalline, form Lewy bodies. Lewy bodies are a hallmark pathological feature of Parkinsons disease and other neurodegenerative diseases. Alpha synuclein has several possible phosphorylation sites, Ser129 in particular can be phosphorylated by Gproteincoupled receptor kinases. Studies suggest that this phosphorylation promotes formation of alpha synuclein filaments, with hyperphosphorylation of Ser129 seen in Lewy bodies.Synonyms: NACP, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, PARK1
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基因ID
- 6622
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NCBI登录号
- NP_000336
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UniProt
- P37840
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途径
- Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity
抗原
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