TNNI3 抗体
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北京 101111
Quick Overview for TNNI3 抗体 (ABIN318833)
抗原
See all TNNI3 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody recognises human cardiac-specific troponin I, (TnI) an integral inhibitory protein of cardiac muscle which exists as a complex with troponin C (TnC) and troponin T (TnT).
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纯化方法
- Purified IgG prepared by Immunoaffinity chromatography
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免疫原
- Native human cardiac troponin I, purity greater than 98%.
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亚型
- IgG
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应用备注
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ELISA.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0mg/mL
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缓冲液
- PBS buffer pH 7.4 containing 0.09 % Sodium Azide (NaN3)
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储存液
- Sodium azide
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注意事项
- This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- TNNI3 (Cardiac Troponin I (TNNI3))
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别名
- Cardiac Troponin I
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背景
- The TnT subunit of troponin binds to tropomyosin to form a troponin-tropomyosin complex, anchored in place by the binding of TnI to actin, within muscle thin filaments. Structural change resulting from the binding of calcium to specific sites on the regulatory TnC subunit, releases the inhibitory region of TnI from actin, enabling the attachment of the molecular motor protein myosin, allowing for muscle contraction and hence movement. The measurement of blood TnI and TnT levels is an important diagnostic indicator of heart muscle damage, and can be used to differentiate between angina and myocardic infarction in patients with chest pain. Troponin I has also been shown to inhibit angiogenesis in vivo and in vitro.Synonyms: TNNC1, TNNI3
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基因ID
- 7137
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NCBI登录号
- NP_000354
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UniProt
- P19429
抗原
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