BAG1 抗体 (C-Term)
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Quick Overview for BAG1 抗体 (C-Term) (ABIN318738)
抗原
See all BAG1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- This antibody detects an epitope within the C-terminal (CT) region of Bcl-2 associated athanogene-1 (BAG1).
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纯化方法
- Purified
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免疫原
- 14 amino acid peptide from near the carboxy terminus of human BAG1.
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亚型
- IgG
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应用备注
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Western Blot: 1 - 2g/mL, detects a band of approximately 39 kDa in PC3 cell lysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0mg/mL
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缓冲液
- Phosphate buffered saline containing 0.02 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- BAG1 (BCL2-Associated Athanogene (BAG1))
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别名
- BAG1
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背景
- BAG1 is a co-chaperone protein which binds to and regulates the 70kD heat shock proteins (Hsp70/Hsc70). BAG1 has also been shown to interact with the kinase Raf1, a number of steroid and tyrosine kinase receptors, and the Bcl-2 family of proteins. It is thought to function as a molecular switch between cell growth and differentiation, and cell survival. The BAG1 gene encodes three different isoforms, a predominantly cytosolic form of 36kD (BAG1S), a 46kD cytosolic and nuclear form (BAG1M), and a predominantly nuclear form 50kD (BAG1L). BAG1 displays potent neuroprotective activity in vivo against stroke, and could be used for reducing brain injury during cerebral ischemia and neurodegenerative diseases. BAG1 may also promote chemoresistance, growth factor independence, and anchorage independent cell growth in tumour cells.Synonyms: BAG family molecular chaperone regulator 1, BAG-1, Bcl-2-associated athanogene 1, Glucocorticoid receptor-associated protein RAP46, HAP, RAP46
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基因ID
- 573
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NCBI登录号
- NP_001165886
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UniProt
- Q99933
抗原
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