Cadherin 13 抗体 (N-Term)
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北京 101111
Quick Overview for Cadherin 13 抗体 (N-Term) (ABIN318711)
抗原
See all Cadherin 13 (CDH13) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- This antibody recognises T-Cadherin.
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纯化方法
- Affinity Chromatography.
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免疫原
- Synthetic peptide corresponding to N-terminus of human Cadherin-13.
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亚型
- IgG
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应用备注
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Western Blot (0.5-1.0 μg/mL): This antibody detects a band/s of approximately 78 kDa in3T3 cell lysates.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- PBS containing 0.02 % Sodium Azide as preservative.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid multiple freeze/thaw cycles.
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- Cadherin 13 (CDH13)
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别名
- Cadherin-13
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背景
- T-cadherin is a 78 kDa, calcium-dependent, glycoprotein. While T-cadherin is a member of the cadherin family, it lacks their conserved cytoplasmic region, being instead anchored to the plasma membrane via glycosylphosphatidylinositol linkage. It is expressed in the heart and CNS with the exception of the cerebellum and spinal cord. Cadherin 13 is classified as a cell-cell adhesion molecule, although it is likely that it's role is in signalling and not physical adhesion. It is involved in regulating low-density lipoprotein-initiated cell proliferation, keratinocyte proliferation, neural cell growth and may play a role in metabolic regulation. Cadherin 13 protects endothelial cells from oxidative stress-induced apoptosis and may contribute to progression of vascular disorders such as atherosclerosis, restenosis and tumour angiogenesis.Synonyms: CDH13, CDHH, Cadherin H, Cadherin T, H-Cadherin, Heart cadherin, P105, T-Cadherin, Truncated cadherin
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基因ID
- 1012
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NCBI登录号
- NP_001248
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UniProt
- P55290
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途径
- EGFR Signaling Pathway, Cell-Cell Junction Organization
抗原
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