NCOA1 抗体 (pTyr418)
Our Local Distributor
北京 101111
Quick Overview for NCOA1 抗体 (pTyr418) (ABIN318122)
抗原
See all NCOA1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- pTyr418
-
特异性
- This antibody detects endogenous levels of SRC pTyr418 protein.
-
纯化方法
- Affinity Chromatography using epitope-specific immunogen.
-
-
anti-Nuclear Receptor Coactivator 1 (NCOA1) (AA 1222-1441) antibody
NCOA1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Coactivator 1 (NCOA1) antibodyNCOA1 适用: 人 WB, IP 宿主: 兔 Monoclonal unconjugated
anti-Nuclear Receptor Coactivator 1 (NCOA1) (pTyr529) antibodyNCOA1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Coactivator 1 (NCOA1) (AA 1338-1367) antibodyNCOA1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Coactivator 1 (NCOA1) (AA 201-300) antibodyNCOA1 适用: 小鼠 WB, ELISA, IHC (p), IF (p), IF (cc), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Coactivator 1 (NCOA1) (AA 284-393) antibodyNCOA1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Coactivator 1 (NCOA1) antibodyNCOA1 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Coactivator 1 (NCOA1) (N-Term) antibodyNCOA1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Coactivator 1 (NCOA1) (AA 611-660) antibodyNCOA1 适用: 人, 大鼠, 犬, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Coactivator 1 (NCOA1) antibodyNCOA1 适用: 人 DB 宿主: 小鼠 Monoclonal 3532C6a unconjugated
-
-
应用备注
-
ELISA: 1/20000-1/40000. Western Blot: 1/500-1/1000. Immunohistochemistry: 1/50-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
-
-
-
浓度
- 1.0 mg/mL
-
缓冲液
- Phosphate buffered saline (PBS), pH ~7.2 containing 0.05 % Sodium Azide as preservative.
-
储存液
- Sodium azide
-
注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freezing and thawing.
-
储存条件
- 4 °C/-20 °C
-
储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
-
-
- NCOA1 (Nuclear Receptor Coactivator 1 (NCOA1))
-
别名
- SRC1
-
背景
- The SRC gene is similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. Mutations in this gene could be involved in the malignant progression of colon cancer. The protein product is pp60vsrc, a cytoplasmic protein with tyrosine-specific protein kinase activity that associates with the cytoplasmic face of the plasma membrane. The protein consists of three domains, an N-terminal SH3 domain, a central SH2 domain and a tyrosine kinase domain. The SH2 and SH3 domains cooperate in the auto-inhibition of the kinase domain. c-Src is phosphorylated on an inhibitory tyrosine near the c-terminus of the protein. This produces a binding site for the SH2 domain which, when bound, facilitates binding of the SH3 domain to a low affinity polyproline site within the linker between the SH2 domain and the kinase domain. Binding of the SH3 domain results in misalignment of residues within the kinase domain's active site inactivating the enzyme. This allows for multiple mechanism for c-Src activation: dephosphorylation of the C-terminal tyrosine by a protein tyrosine phosphatase, binding of the SH2 domain by a competitive phospho-tyrosine residue, as seen in the case of c-Src binding to focal adhesion kinase, or competitive binding of a polyproline binding site to the SH3 domain, as seen in the case of the HIV NEF protein.Synonyms: Proto-oncogene c-Src, Proto-oncogene tyrosine-protein kinase Src, c-Src, pp60c-src
-
分子量
- approx. 60 kDa
-
基因ID
- 6714
-
NCBI登录号
- NP_005408
-
UniProt
- P12931
-
途径
- Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha
抗原
-
