ADCY4 抗体
Quick Overview for ADCY4 抗体 (ABIN317941)
抗原
See all ADCY4 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- A Cyclase IV antibody detects endogenous levels of A Cyclase IV protein.(region surrounding Leu226)
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纯化方法
- Affinity chromatography
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anti-Adenylate Cyclase 4 (ADCY4) antibody
ADCY4 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Adenylate Cyclase 4 (ADCY4) (Internal Region) antibodyADCY4 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Adenylate Cyclase 4 (ADCY4) (AA 808-1077) antibodyADCY4 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Adenylate Cyclase 4 (ADCY4) (Internal Region) antibodyADCY4 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Adenylate Cyclase 4 (ADCY4) (AA 352-541) antibodyADCY4 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Adenylate Cyclase 4 (ADCY4) (AA 415-441) antibodyADCY4 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB23657 unconjugated
anti-Adenylate Cyclase 4 (ADCY4) (AA 421-450), (Middle Region) antibodyADCY4 适用: 人 WB, EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1,0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- ADCY4 (Adenylate Cyclase 4 (ADCY4))
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别名
- Adenylate Cyclase Type 4
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背景
- Adenylyl cyclases function to convert ATP to cyclic AMP in response to activation by a variety of hormones, neurotransmitters and other regulatory molecules. Cyclic AMP, in turn, activates several other target molecules to control a broad range of diverse phenomena such as metabolism, gene transcription and memory. Adenylyl cyclases respond to receptor-initiated signals, mediated by the Gs and Gi heterotrimeric G proteins. The binding of an agonist to a Gs-coupled receptor catalyzes the exchange of GDP (bound to Gα s) for GTP, the dissociation of GTP-Gα s from Gβγ and Gα s-mediated activation of adenylyl cyclase. Adenylyl cyclase IV (AC IV) and IX mRNA are expressed in all kidney nephron segments. AC IV exhibits moderate staining in type II and type IV fibrocytes in rat cochlea and immunoreactivity is also observed in type I fibrocytes. Activation of the D2 dopaminergic and m4 muscarine receptors inhibits the activity of adenylyl cyclase isozymes I, V, VI and VIII, whereas type II, IV and VII are stimulated and type III is not affected.Synonyms: ADCY4, ATP pyrophosphate-lyase 4, Adenylate cyclase type IV, Adenylyl cyclase 4
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分子量
- approx. 120 kDa
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基因ID
- 196883
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NCBI登录号
- NP_001185497
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UniProt
- Q8NFM4
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途径
- EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, cAMP Metabolic Process, Myometrial Relaxation and Contraction, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma
抗原
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